Yu Jia Chang

TL;DR: The findings implicate the involvement of both androgens and the AR in bladder cancer, and Targeting AR and androgens may provide novel chemopreventive and therapeutic approaches for bladder cancer.

TL;DR: Adding 5-hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one (ASC-J9) disrupts the interaction between AR and its coregulators, and also increases cell survival by decreasing AR- polyQ nuclear aggregation and increasing AR-polyQ degradation in cultured cells, which point to a better therapeutic and preventative approach to treating SBMA.

TL;DR: The alpha9-nAChR is important for nicotine-induced transformation of normal human breast epithelial cells and triggered precancerous transformation as defined by soft agar assay.

TL;DR: Together, these PM-AR−/y mice provide in vivo evidence for the requirement of functional AR in peritubular myoid cells to maintain normal Sertoli cells function and peritubsic myoid cell contractility, thus ensuring normal spermatogenesis and sperm output.

TL;DR: The homeostatic regulation of cyclin D3 has the potential to be a molecular target for antitumor chemotherapeutic or chemopreventive purposes in clinical breast cancer patients.