Yuan Ma

TL;DR: This work re-port CRISPR-Cas12a sensors that are regulated by functional DNA (fDNA) molecules such as aptamers and DNAzymes that are selective for small organic molecule and metal ion detections that are suitable for field tests or point-of-care diagnostics.

TL;DR: The crosslinked nanogels can assist the delivery of siRNAs into different cells without any transfection agents and achieve the gene silencing effectively both in’vitro and in vivo, through which a significant inhibition of tumor growth is realized in the anticancer treatment.

TL;DR: A novel targeting small molecule nanodrug self-delivery system consisting of targeting ligand and chemotherapy drug was constructed and showed excellent targeting ability and long blood circulation time with well-defined structure, high drug loading ratio and on-demand drug release behavior.

TL;DR: With precise control over the drug-loading ratio and structure of the nanocarriers, the DNA Trojan horse may play an important role in anticancer treatment and exhibit great potential in translational nanomedicine.

TL;DR: A novel approach to synthesize a nanosized DDS using drug-integrated DNA with antisense sequences (termed "chemogene") to treat drug-resistant cancer is reported, which possesses the capabilities of rapid cell entry without the need for a transfection agent, efficient downregulation of drug resistance genes, and chronic release of chemotherapeutics for treating the drug- resistant tumors in both subcutaneous and orthotopic liver transplantation mouse models.