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Yuanyan Xiong
Researcher at Sun Yat-sen University
Publications - 32
Citations - 675
Yuanyan Xiong is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 9, co-authored 12 publications receiving 529 citations. Previous affiliations of Yuanyan Xiong include Carnegie Mellon University.
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Journal ArticleDOI
Correction of β-thalassemia mutant by base editor in human embryos
Puping Liang,Chenhui Ding,Hongwei Sun,Xiaowei Xie,Yanwen Xu,Xiya Zhang,Ying Sun,Yuanyan Xiong,Wenbin Ma,Yongxiang Liu,Yali Wang,Jianpei Fang,Dan Liu,Zhou Songyang,Zhou Songyang,Canquan Zhou,Junjiu Huang +16 more
TL;DR: The feasibility of curing genetic disease in human somatic cells and embryos by base editor system is demonstrated and base editor variants, with narrowed deamination window, could promote G-to-A conversion at HBB −28 site precisely in human embryos.
Journal ArticleDOI
Human telomeric proteins occupy selective interstitial sites
Dong Yang,Yuanyan Xiong,Hyeung Kim,Quanyuan He,Yumei Li,Rui Chen,Zhou Songyang,Zhou Songyang +7 more
TL;DR: The results indicate that human telomeric proteins could occupy a limited number of interstitial sites and regulate gene transcription.
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Genome-wide profiling of adenine base editor specificity by EndoV-seq
Puping Liang,Xiaowei Xie,Xiaowei Xie,Shengyao Zhi,Hongwei Sun,Xiya Zhang,Yu Chen,Yuxi Chen,Yuanyan Xiong,Wenbin Ma,Dan Liu,Junjiu Huang,Zhou Songyang +12 more
TL;DR: This study presents the first detection method to evaluate genome-wide off-target effects of ABE, and reveals possible similarities and differences between ABE and canonical Cas9 nuclease.
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The Trithorax Group Protein Ash2l Is Essential for Pluripotency and Maintaining Open Chromatin in Embryonic Stem Cells
Ma Wan,Jiancong Liang,Yuanyan Xiong,Feng-Tao Shi,Yi Zhang,Weisi Lu,Quanyuan He,Dong Yang,Rui Chen,Dan Liu,Michelle Craig Barton,Michelle Craig Barton,Zhou Songyang,Zhou Songyang +13 more
TL;DR: It is demonstrated that trithorax protein Ash2l, homologue of the Drosophila Ash2 (absent, small, homeotic-2) protein, is a key regulator of open chromatin in ES cells.
Journal ArticleDOI
Effective gene editing by high-fidelity base editor 2 in mouse zygotes
Puping Liang,Hongwei Sun,Ying Sun,Xiya Zhang,Xiaowei Xie,Jinran Zhang,Zhen Zhang,Yuxi Chen,Chenhui Ding,Yuanyan Xiong,Wenbin Ma,Dan Liu,Junjiu Huang,Zhou Songyang +13 more
TL;DR: The feasibility of generating point mutations in mouse by base editing is demonstrated, and the need to carefully optimize base editing systems in order to eliminate proximal-site deamination is underscored.