CD44 expression identifies astrocyte-restricted precursor cells
Ying Liu,Ying Liu,Steve S.W. Han,Yuanyuan Wu,Thérèse M. F. Tuohy,Haipeng Xue,Jingli Cai,Jingli Cai,Stephen A. Back,Larry S. Sherman,Itzhak Fischer,Mahendra S. Rao +11 more
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TLDR
The data provide strong evidence for the existence of a CD44+ ARP in the developing nervous system, which can be generated from GRP cells in mass or clonal cultures and in vivo after transplantation, suggesting a sequential differentiation of neuroepithelial stem cells to GRPs to ARPs and then to astrocytes.About:
This article is published in Developmental Biology.The article was published on 2004-12-01 and is currently open access. It has received 197 citations till now. The article focuses on the topics: Neuroepithelial cell & Neurosphere.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
The therapeutic potential of neural stem cells.
TL;DR: In this article, the authors discuss the alternative bystander mechanism in the context of the atypical ectopic perivascular niche and propose that it is the most challenging example of reciprocal therapeutic crosstalk between the inflamed CNS and systemically transplanted neural stem cells.
Journal ArticleDOI
The bioink: A comprehensive review on bioprintable materials.
TL;DR: This paper presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes.
Journal ArticleDOI
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Stephen A. Back,Thérèse M. F. Tuohy,Hanqin Chen,Nicholas Wallingford,Andrew Craig,Jaime Struve,Ning Ling Luo,Fatima Banine,Ying Liu,Ansi Chang,Bruce D. Trapp,Bruce F. Bebo,Mahendra S. Rao,Larry S. Sherman +13 more
TL;DR: It is found that the glycosaminoglycan hyaluronan accumulates in demyelinated lesions from individuals with multiple sclerosis and in mice with experimental autoimmune encephalomyelitis.
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Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.
TL;DR: G1 lengthening is necessary and sufficient to switch neural progenitors to neurogenesis, and overexpression of cdk4/cyclinD1 can be used to increase progenitor expansion and, perhaps, cortical surface area.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
TL;DR: It is suggested that fibrous astrocytes and oligodendrocyte develop from a common progenitor cell and provide a striking example of developmental plasticity and environmental influence in the differentiation of CNS glial cells.
Journal ArticleDOI
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Qiao Zhou,David J. Anderson +1 more
TL;DR: The results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendroCytes, the three fundamental cell types of the central nervous system.
Journal ArticleDOI
Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection
TL;DR: Targeted disruption of Olig1 and Olig2 genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors, indicating that oligod endodendrocytes are derived from Olig-specified progenitor that give rise also to neurons.
Book ChapterDOI
CD44: Structure, Function and Association with the Malignant Process
TL;DR: It has been shown in animal models that injection of reagents interfering with CD44-ligand interaction inhibit local tumor growth and metastatic spread and suggest that CD44 may confer a growth advantage on some neoplastic cells and, therefore, could be used as a target for cancer diagnosis.