Yue Gu

TL;DR: H2S attenuates diabetes-accelerated atherosclerosis, which may be related to inhibition of oxidative stress via Keap1 sulfhydrylation at Cys151 to activate Nrf2 signaling.

TL;DR: A novel role for SIRT3 is highlighted in the protective effect of H2S against oxidant damage in the endothelium both in vitro and in vivo, thereby reducing oxidant-provoked vascular endothelial dysfunction.

TL;DR: Results show that celastrol inhibits atherosclerotic plaque developing in apoE−/− mice via inhibiting LOX-1 and oxidative stress.

TL;DR: H2 S-mediated Keap1 S-sulfhydration alleviates liver damage via activation of Nrf2 and may be of therapeutic benefit in the context of concurrent hyperlipidemia and hyperglycemia-induced or CCl4 -stimulated liver dysfunction.

TL;DR: Findings suggest that H2S regulates KLF5 transcription activity via specificity protein 1 S‐sulfhydration at Cys664 to prevent myocardial hypertrophy.