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Yueh Chien
Researcher at National Yang-Ming University
Publications - 27
Citations - 1028
Yueh Chien is an academic researcher from National Yang-Ming University. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 12, co-authored 27 publications receiving 828 citations. Previous affiliations of Yueh Chien include Taipei Veterans General Hospital & National Chiao Tung University.
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Journal ArticleDOI
Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.
Yi Ping Yang,Yueh Chien,Guang-Yuh Chiou,Guang-Yuh Chiou,Jong Yuh Cherng,Mong Lien Wang,Wen Liang Lo,Yuh Lih Chang,Pin I. Huang,Yi Wei Chen,Yang Hsin Shih,Ming Teh Chen,Shih Hwa Chiou +12 more
TL;DR: It is demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133(+) cells and malignant glioma specimens, and PU-PEI-miR145 is a novel therapeutic approach for malignant brain tumors.
Journal ArticleDOI
Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma.
Guang-Yuh Chiou,Jong Yuh Cherng,Han Shui Hsu,Mong Lien Wang,Chun Ming Tsai,Kai Hsi Lu,Yueh Chien,Shih-Chieh Hung,Yi Wei Chen,Chiang Ing Wong,Ling Ming Tseng,Pin I. Huang,Cheng Chia Yu,Wen Huh Hsu,Shih Hwa Chiou +14 more
TL;DR: In vivo study showed that PU-PEI-mediated miR145 delivery to xenograft tumors reduced tumor growth and metastasis, sensitized tumors to chemoradiotherapies, and prolonged the survival times of tumor-bearing mice.
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Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma
Guang-Yuh Chiou,Chian Shiu Chien,Mong Lien Wang,Ming Teh Chen,Yi Ping Yang,Yung Luen Yu,Yueh Chien,Yun Ching Chang,Chiung Chyi Shen,Chung Ching Chio,Kai Hsi Lu,Hsin I. Ma,Kuan Hsuan Chen,Dean-Mo LIu,Stephanie A. Miller,Yi Wei Chen,Pin I. Huang,Yang Hsin Shih,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung,Shih Hwa Chiou +21 more
TL;DR: An IL-6/miR142-3p feedback-loop-dependent regulation of GBM malignancy that could be a potential therapeutic target is discovered.
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Induced pluripotent stem cells without c-Myc attenuate acute kidney injury via downregulating the signaling of oxidative stress and inflammation in ischemia-reperfusion rats.
Pei Ying Lee,Yueh Chien,Yueh Chien,Guang-Yuh Chiou,Guang-Yuh Chiou,Chi Hung Lin,Chih Hwa Chiou,Chih Hwa Chiou,Der Cherng Tarng,Der Cherng Tarng +9 more
TL;DR: Considering the antioxidant, anti-inflammatory, and antiapoptotic properties of iPS cells without c-Myc, transplantation of such cells may be a treatment option for ischemic AKI.
Journal ArticleDOI
Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc
Shih Hwa Chiou,Bo Hwa Jiang,Yung Luen Yu,Yung Luen Yu,Shih Jie Chou,Ping Hsing Tsai,Wei Chao Chang,Wei Chao Chang,Liang Kung Chen,Li Hsin Chen,Yueh Chien,Guang-Yuh Chiou +11 more
TL;DR: Parp1 can replace c-Myc to promote induced pluripotent stem cell (iPSC) generation and may also be a source of infection for other stem cell types.