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Yueju Su
Researcher at Georgia State University
Publications - 3
Citations - 632
Yueju Su is an academic researcher from Georgia State University. The author has contributed to research in topics: Colitis & TLR5. The author has an hindex of 3, co-authored 3 publications receiving 517 citations. Previous affiliations of Yueju Su include Emory University.
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Journal ArticleDOI
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Frederic A. Carvalho,Frederic A. Carvalho,Frederic A. Carvalho,Omry Koren,Julia K. Goodrich,Malin E. V. Johansson,ILKe Nalbantoglu,Jesse D. Aitken,Yueju Su,Benoit Chassaing,William A. Walters,Antonio Gonzalez,Jose C. Clemente,Tyler C. Cullender,Nicolas Barnich,Arlette Darfeuille-Michaud,Matam Vijay-Kumar,Rob Knight,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +20 more
TL;DR: An innate immune deficiency can result in unstable gut microbiota associated with low-grade inflammation, and harboring proteobacteria can drive and/or instigate chronic colitis.
Journal ArticleDOI
Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
Frederic A. Carvalho,ILKe Nalbantoglu,Jesse D. Aitken,Robin Uchiyama,Yueju Su,Gregory H. Doho,Matam Vijay-Kumar,Andrew T. Gewirtz,Andrew T. Gewirtz +8 more
TL;DR: Despite not being involved in rapid intestinal gene remodeling upon detection of flagellin, NLRC4-mediated inflammasome activation results in production of IL-1β and IL-18, two cytokines that protect mice from mucosal and systemic challenges.
Journal ArticleDOI
Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
Frederic A. Carvalho,ILKe Nalbantoglu,Sophie Ortega-Fernandez,Jesse D. Aitken,Yueju Su,Omry Koren,William A. Walters,Rob Knight,Ruth E. Ley,Matam Vijay-Kumar,Andrew T. Gewirtz +10 more
TL;DR: Regardless of whether they harbour a colitogenic microbiota, loss of TLR5 predisposes mice to colitis triggered by immune dysregulation via an IL-1β-dependent pathway.