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Yuk On Chan
Researcher at University of Hong Kong
Publications - 4
Citations - 952
Yuk On Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Chemokine receptor & Chemokine. The author has an hindex of 3, co-authored 4 publications receiving 875 citations. Previous affiliations of Yuk On Chan include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
Michael C. W. Chan,CY Cheung,WH Chui,S W Tsao,John M. Nicholls,Yuk On Chan,Renee W. Y. Chan,H T Long,Leo L.M. Poon,Yi Guan,Joseph S. M. Peiris +10 more
TL;DR: The H5n1/97 and H5N1/04 subtype influenza A viruses are more potent inducers of proinflammatory cytokines and chemokines in primary human respiratory epithelial cells than subtype H1N1 virus, and it is suggested that this hyper-induction of cytokines may be relevant to the pathogenesis of human H4N1 disease.
Journal ArticleDOI
Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells.
Helen K. W. Law,Chung Yan Cheung,Hoi Yee Ng,Sin Fun Sia,Yuk On Chan,Winsie Luk,John M. Nicholls,J. S. Malik Peiris,Yu-Lung Lau +8 more
TL;DR: No increase in virus titer was detected in infected DCs and cell-culture supernatant, confirming that virus replication was incomplete and the lack of antiviral cytokine response against a background of intense chemokine up-regulation could represent a mechanism of immune evasion by SARS-CoV.
Journal ArticleDOI
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
TL;DR: The upregulation of chemokines and CCRs may facilitate DC migration from the infection site to the lymph nodes, whereas the increase of TRAIL may induce lymphocyte apoptosis, which may explain the increased lung infiltrations and lymphoid depletion in SARS patients.