R
Renee W. Y. Chan
Researcher at The Chinese University of Hong Kong
Publications - 89
Citations - 4870
Renee W. Y. Chan is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 28, co-authored 71 publications receiving 4294 citations. Previous affiliations of Renee W. Y. Chan include University of Hong Kong & University of Michigan.
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Journal ArticleDOI
Unravelling the Role of O-glycans in Influenza A Virus Infection
Juliane Mayr,Kam Lau,Jimmy C. C. Lai,Ivan A. Gagarinov,Yun Shi,Sarah McAtamney,Renee W. Y. Chan,John M. Nicholls,Mark von Itzstein,Thomas Haselhorst +9 more
TL;DR: It is suggested that sialylated Galβ(1,3)GalNAc as O-glycan core 1 glycoforms are involved in the influenza A virus life cycle and play a particularly crucial role during infection of HPAI strains.
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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
Michael C. W. Chan,CY Cheung,WH Chui,S W Tsao,John M. Nicholls,Yuk On Chan,Renee W. Y. Chan,H T Long,Leo L.M. Poon,Yi Guan,Joseph S. M. Peiris +10 more
TL;DR: The H5n1/97 and H5N1/04 subtype influenza A viruses are more potent inducers of proinflammatory cytokines and chemokines in primary human respiratory epithelial cells than subtype H1N1 virus, and it is suggested that this hyper-induction of cytokines may be relevant to the pathogenesis of human H4N1 disease.
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Evolving complexities of influenza virus and its receptors.
TL;DR: It is suggested that the distribution and detection of these terminal Siaalpha2-3- and Sia alpha2-6-linked receptors within the respiratory tract might not be as clear cut as has been reported.
Journal ArticleDOI
Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection.
Trevenan Walther,Rositsa Karamanska,Renee W. Y. Chan,Renee W. Y. Chan,Michael C. W. Chan,Nan Jia,Gillian M. Air,Clark Hopton,Maria P. Wong,Anne Dell,J. S. Malik Peiris,Stuart M. Haslam,John M. Nicholls +12 more
TL;DR: The most comprehensive array from the Consortium for Functional Glycomics contained the greatest diversity of sialylated glycans, but was not predictive of productive replication in the bronchus and lung.
Journal ArticleDOI
Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets
Hui-Ling Yen,Chi-Hui Liang,Chung-Yi Wu,Heather L. Forrest,Angela Ferguson,Ka-Tim Choy,Jeremy C. Jones,Diana Dik-Yan Wong,Peter Pak-Hang Cheung,Che-Hsiung Hsu,Olive T. W. Li,Kit M. Yuen,Renee W. Y. Chan,Leo L.M. Poon,Michael C. W. Chan,John M. Nicholls,Scott Krauss,Chi-Huey Wong,Yi Guan,Robert G. Webster,Richard J. Webby,Malik Peiris +21 more
TL;DR: The results suggest that a unique gene constellation and hemagglutinin–neuraminidase balance play a critical role in acquisition of efficient and sustained human-to-human transmissibility.