Yukiko Fujita

TL;DR: The similarities in the phenotypes of the MILI- and MVH-deficient mice and in the physical binding properties of MILI and MVh indicate a functional association of these proteins in post-transcriptional regulation, and indicate that MILI is essential for the differentiation of spermatocytes.

TL;DR: Experiments with PTEN-null PGCs in culture revealed that these cells had greater proliferative capacity and enhanced pluripotent embryonic germ (EG) cell colony formation, and PTEN appears to be essential for germ cell differentiation and an important factor in testicular germ cell tumor formation.

TL;DR: The deduced amino acid sequences of mouse homologues MIWI and MILI showed that each contains a well-conserved C-terminal PIWI domain and that each shares significant homology with PIWI and their human counterparts HIWI.

TL;DR: Investigation of gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells and a novel gene, PGC7, which was preferentially expressed in PGCs suggested that it might play an important role in the development of P GCs and oocytes.

TL;DR: Results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development.