T
Tohru Kimura
Researcher at Kitasato University
Publications - 77
Citations - 8222
Tohru Kimura is an academic researcher from Kitasato University. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 33, co-authored 71 publications receiving 7747 citations. Previous affiliations of Tohru Kimura include University of Toronto & University of Tsukuba.
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Journal ArticleDOI
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
Satomi Kuramochi-Miyagawa,Toshiaki Watanabe,Kengo Gotoh,Yasushi Totoki,Atsushi Toyoda,Masahito Ikawa,Noriko Asada,Kanako Kojima,Yuka Yamaguchi,Takashi W. Ijiri,Kenichiro Hata,En Li,Yoichi Matsuda,Tohru Kimura,Masaru Okabe,Yoshiyuki Sakaki,Hiroyuki Sasaki,Toru Nakano,Toru Nakano +18 more
TL;DR: In this paper, DNA methylation and Piwi-interacting small RNA (piRNA) expression were analyzed in wild-type, MILI-null, and MIWI2-null male fetal germ cells.
Journal ArticleDOI
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.
Ryutaro Kamijo,Hisashi Harada,Toshifumi Matsuyama,Maarten C. Bosland,J. Gerecitano,Deborah Shapiro,Junming Le,S. I. Koh,Tohru Kimura,Shawn J. Green,T. W. Mak,Tadatsugu Taniguchi,Jan Vilcek +12 more
TL;DR: Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation, and infection with Mycobacterium bovis was more severe in IRf-1-/- mice than in wild-type mice.
Journal ArticleDOI
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Satomi Kuramochi-Miyagawa,Tohru Kimura,Takashi W. Ijiri,Taku Isobe,Noriko Asada,Yukiko Fujita,Masahito Ikawa,Naomi Iwai,Masaru Okabe,Wei Deng,Haifan Lin,Yoichi Matsuda,Toru Nakano +12 more
TL;DR: The similarities in the phenotypes of the MILI- and MVH-deficient mice and in the physical binding properties of MILI and MVh indicate a functional association of these proteins in post-transcriptional regulation, and indicate that MILI is essential for the differentiation of spermatocytes.
Journal ArticleDOI
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
Toshifumi Matsuyama,Toshifumi Matsuyama,Tohru Kimura,Tohru Kimura,Tohru Kimura,Motoo Kitagawa,Klaus Pfeffer,Klaus Pfeffer,Takatoshi Kawakami,Nobumasa Watanabe,Thomas M. Kündig,Ryuichi Amakawa,Ryuichi Amakawa,Kenji Kishihara,Kenji Kishihara,Andrew Wakeham,Andrew Wakeham,Julia Potter,Julia Potter,Caren Furlonger,Arumugavadivel Narendran,Haruhiko Suzuki,Haruhiko Suzuki,Pamela S. Ohashi,Christopher J. Paige,Tadatsugu Taniguchi,Tak W. Mak,Tak W. Mak +27 more
TL;DR: A profound reduction of TCR alpha beta+CD4-CD8+ T cells in IRF-1-deficient mice, with a thymocyte developmental defect, reveals a critical role for IRF -1 in T cell development.
Journal ArticleDOI
PGC7/Stella protects against DNA demethylation in early embryogenesis.
Toshinobu Nakamura,Yoshikazu Arai,Hiroki Umehara,Masaaki Masuhara,Tohru Kimura,Hisaaki Taniguchi,Toshihiro Sekimoto,Masahito Ikawa,Yoshihiro Yoneda,Masaru Okabe,Satoshi Tanaka,Kunio Shiota,Toru Nakano +12 more
TL;DR: It is shown that PGC7/Stella, a maternal factor essential for early development, protects the DNA methylation state of several imprinted loci and epigenetic asymmetry in maternal genome after fertilization.