Y
Yukio Ishimi
Researcher at Ibaraki University
Publications - 58
Citations - 3320
Yukio Ishimi is an academic researcher from Ibaraki University. The author has contributed to research in topics: DNA replication & Control of chromosome duplication. The author has an hindex of 27, co-authored 58 publications receiving 3201 citations. Previous affiliations of Yukio Ishimi include Mitsubishi & Gyeongsang National University.
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Journal ArticleDOI
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex *
TL;DR: Results suggest that this helicase may be involved in the initiation of DNA replication as a DNA unwinding enzyme.
Journal ArticleDOI
The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.
Hirochika Kitagawa,Hirochika Kitagawa,Ryoji Fujiki,Kimihiro Yoshimura,Yoshihiro Mezaki,Yoshikatsu Uematsu,Daisuke Matsui,Satoko Ogawa,Kiyoe Unno,Kiyoe Unno,Mataichi Okubo,Akifumi Tokita,Takeya Nakagawa,Takashi Ito,Yukio Ishimi,Hiromichi Nagasawa,Toshio Matsumoto,Junn Yanagisawa,Shigeaki Kato +18 more
TL;DR: The identification of a human multiprotein complex (WINAC) that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF) suggests that WINAC dysfunction contributes to Williams syndrome, which could therefore be considered, at least in part, a chromatin-remodeling factor disease.
Journal ArticleDOI
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis
Kyosuke Nagata,Hiroyuki Kawase,Hiroshi Handa,K Yano,Masanori Yamasaki,Yukio Ishimi,A Okuda,Akira Kikuchi,Ken Matsumoto +8 more
TL;DR: The cloning of two human cDNAs encoding TAF-I is described, which revealed that the 39-kDa polypeptide corresponds to the protein encoded by the set gene, which is the part of the putative oncogene associated with acute undifferentiated leukemia when translocated to the can gene.
Journal ArticleDOI
Identification and molecular cloning of yeast homolog of nucleosome assembly protein I which facilitates nucleosome assembly in vitro.
Yukio Ishimi,Akira Kikuchi +1 more
TL;DR: The amino acid sequence deduced from the gene coding for the yeast NAP-I defines a polypeptide of molecular mass 47,848 Da with three negatively charged regions that is probably involved in the interaction with histones.
Journal ArticleDOI
Human Cdc7-related Kinase Complex: IN VITRO PHOSPHORYLATION OF MCM BY CONCERTED ACTIONS OF Cdks AND Cdc7 AND THAT OF A CRITICAL THREONINE RESIDUE OF Cdc7 BY Cdks *
TL;DR: Replacement of Thr-376, corresponding to the activating threonine of Cdk, with alanine (T376A mutant) dramatically reduces kinase activity, indicative of kinase activation by phosphorylation of this residue.