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Yukio Ozaki
Researcher at University of Yamanashi
Publications - 323
Citations - 12318
Yukio Ozaki is an academic researcher from University of Yamanashi. The author has contributed to research in topics: Platelet activation & Platelet. The author has an hindex of 56, co-authored 283 publications receiving 11088 citations. Previous affiliations of Yukio Ozaki include University of Tennessee Health Science Center & University of Tokyo.
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Journal ArticleDOI
Thrombosis A Major Contributor to Global Disease Burden
Gary E. Raskob,Pantep Angchaisuksiri,Alicia N. Blanco,Harry R. Büller,Alexander Gallus,Beverley J. Hunt,Elaine M. Hylek,Ajay K. Kakkar,Stavros Konstantinides,M. McCumber,Yukio Ozaki,Aaron M. Wendelboe,Jeffrey I. Weitz +12 more
TL;DR: A systematic review of the literature on the global burden of venous thromboembolism (VTE) in low-, middle-, and high-income countries was performed in this article.
Journal ArticleDOI
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
Katsue Suzuki-Inoue,Gemma L.J. Fuller,Ángel García,Johannes A. Eble,Stefan Pöhlmann,Osamu Inoue,T. Kent Gartner,Sascha Claire Hughan,Andrew C. Pearce,Gavin D. Laing,R. David G. Theakston,Edina Schweighoffer,Nicole Zitzmann,Takashi Morita,Victor L. J. Tybulewicz,Yukio Ozaki,Steve P. Watson +16 more
TL;DR: Findings define a novel signaling pathway in platelets whereby activation of CLEC-2 by rhodocytin leads to tyrosine phosphorylation of its cytosolic tail, binding of Syk and initiation of downstream tyrosination events, and activation of PLCgamma2.
Journal ArticleDOI
Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.
Katsue Suzuki-Inoue,Yukinari Kato,Osamu Inoue,Mika K. Kaneko,Kazuhiko Mishima,Yutaka Yatomi,Yasuo Yamazaki,Hisashi Narimatsu,Yukio Ozaki +8 more
TL;DR: It is suggested that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanIn-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplan in.
Journal Article
Thrombosis: a major contributor to the global disease burden
Gary E. Raskob,Pantep Angchaisuksiri,Alicia N. Blanco,H. R. Büller,Alexander Gallus,Beverley J. Hunt,Elaine M. Hylek,A. K. Kakkar,Stavros Konstantinides,Micah McCumber,Yukio Ozaki,Aaron M. Wendelboe,J. I. Weitz +12 more
TL;DR: VTE associated with hospitalization was the leading cause of disability-adjusted life-years lost in low- and middle- income countries, and second in high-income countries, responsible for more disability- adjusted life- years lost than nosocomial pneumonia, catheter-related blood stream infections, and adverse drug events.
Journal ArticleDOI
Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum
Yutaka Yatomi,Yasuyuki Igarashi,Libo Yang,Nobuo Hisano,Ruomei Qi,Naoki Asazuma,Kaneo Satoh,Yukio Ozaki,Shoji Kume +8 more
TL;DR: The release of Sph-1-P from activated platelets may be involved in a variety of physiological and pathophysiological processes, including thrombosis, hemostasis, atherosclerosis and wound healing.