Yuko Kawano

TL;DR: It is demonstrated that osteocytes, the major cellular component of mature bone, are regulators of HSPC egress and the BM/bone niche interface is critically controlled from inside of the bone matrix and establish an important physiological role for skeletal tissues in hematopoietic function.

TL;DR: A role for osteocytes as critical regulators of lymphopoiesis and fat metabolism is defined and it is suggested that bone acts as a central regulator of multiple organs.

TL;DR: A novel mechanistic insight is provided into the communication of the nervous system, BM niche components, and hematopoietic cells and sympathetic denervation eliminated both neutrophil priming for PGE2 production and fever during G-CSF treatment, identifying sympathetic tone-primed BM neutrophils as one of the major PGE 2 producers.

TL;DR: TFL is a novel gradual and persistent posttranscriptional regulator, and the TFL-driven attenuation of excessive inflammation could contribute to recovery from T cell–mediated autoimmune diseases.

TL;DR: MMF administration of every 8 h after alloSCT would be better to maintain higher MPA plasma levels than that of every 12 h even in the same daily dose, according to real-time pharmacokinetic monitoring.