S
Shinichi Ishii
Researcher at Kobe University
Publications - 12
Citations - 147
Shinichi Ishii is an academic researcher from Kobe University. The author has contributed to research in topics: Bone marrow & Transplantation. The author has an hindex of 6, co-authored 12 publications receiving 98 citations.
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Journal ArticleDOI
G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2
Yuko Kawano,Chie Fukui,Masakazu Shinohara,Kanako Wakahashi,Shinichi Ishii,Tomohide Suzuki,Mari Sato,Mari Sato,Noboru Asada,Hiroki Kawano,Kentaro Minagawa,Akiko Sada,Tomoyuki Furuyashiki,Satoshi Uematsu,Satoshi Uematsu,Shizuo Akira,Toshimitsu Uede,Shuh Narumiya,Toshimitsu Matsui,Yoshio Katayama +19 more
TL;DR: A novel mechanistic insight is provided into the communication of the nervous system, BM niche components, and hematopoietic cells and sympathetic denervation eliminated both neutrophil priming for PGE2 production and fever during G-CSF treatment, identifying sympathetic tone-primed BM neutrophils as one of the major PGE 2 producers.
Journal ArticleDOI
Pharmacokinetics-based optimal dose prediction of donor source-dependent response to mycophenolate mofetil in unrelated hematopoietic cell transplantation
Kanako Wakahashi,Motohiro Yamamori,Kentaro Minagawa,Shinichi Ishii,Shinichirou Nishikawa,Manabu Shimoyama,Hiroki Kawano,Yuko Kawano,Yuriko Kawamori,Akiko Sada,Toshimitsu Matsui,Yoshio Katayama +11 more
TL;DR: The results of this study suggest that individualized MMF dosing in a donor source-dependent fashion may be important for maximizing the benefit of MMF in allo-SCT.
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Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis.
Kanako Wakahashi,Kentaro Minagawa,Yuko Kawano,Hiroki Kawano,Tomohide Suzuki,Shinichi Ishii,Akiko Sada,Noboru Asada,Mari Sato,Shigeaki Kato,Kotaro Shide,Kazuya Shimoda,Toshimitsu Matsui,Yoshio Katayama +13 more
TL;DR: It is shown that myelofibrosis critically depends on macrophages whose differentiation is skewed by vitamin D receptor (VDR) signaling, and it is suggested that VDR and macrophage may be novel therapeutic targets for MPNs with myeloproliferative neoplasms with JAK2V617F mutations.
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Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference in response
Yuka Ishikawa,Shiho Kitaoka,Shiho Kitaoka,Yuko Kawano,Shinichi Ishii,Tomohide Suzuki,Kanako Wakahashi,Taro Kato,Yoshio Katayama,Yoshio Katayama,Tomoyuki Furuyashiki,Tomoyuki Furuyashiki +11 more
TL;DR: The role and regulation of leukocytes in chronic stress remain unclear and blood‐borne cytokines are reported to be crucial for stress‐induced changes in emotional behaviours.
Journal ArticleDOI
Mobilization efficiency is critically regulated by fat via marrow PPARδ.
Tomohide Suzuki,Shinichi Ishii,Masakazu Shinohara,Yuko Kawano,Kanako Wakahashi,Hiroki Kawano,Akiko Sada,Kentaro Minagawa,Michito Hamada,Satoru Takahashi,Tomoyuki Furuyashiki,Nguan Soon Tan,Toshimitsu Matsui,Yoshio Katayama +13 more
TL;DR: In this article, the regulatory mechanism for mobilization efficiency by dietary fat was assessed in mice and the BM mRNA level of peroxisome proliferator-activated receptor δ (PPARδ), a receptor for lipid mediators, was markedly upregulated by granulocyte colony-stimulating factor (G-CSF) in mice fed with ND and displayed a strong positive correlation with widely scattered mobilization efficiency.