Y
Yuko Tadokoro
Researcher at Kanazawa University
Publications - 29
Citations - 1933
Yuko Tadokoro is an academic researcher from Kanazawa University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 15, co-authored 26 publications receiving 1762 citations. Previous affiliations of Yuko Tadokoro include Cancer Research Institute & Kobe Pharmaceutical University.
Papers
More filters
Journal ArticleDOI
TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Kazuhito Naka,Takayuki Hoshii,Teruyuki Muraguchi,Yuko Tadokoro,Takako Ooshio,Yukio Kondo,Shinji Nakao,Noboru Motoyama,Atsushi Hirao +8 more
TL;DR: A critical role for the TGF-β–FOXO pathway in the maintenance of LICs is demonstrated, and the understanding of the mechanisms that specifically maintain CML LICs in vivo is strengthened.
Journal ArticleDOI
Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
Shintaro Tanimura,Shintaro Tanimura,Yuko Tadokoro,Ken Inomata,Nguyen Thanh Binh,Nguyen Thanh Binh,Wataru Nishie,Satoshi Yamazaki,Hiromitsu Nakauchi,Yoshio Tanaka,James R. McMillan,Daisuke Sawamura,Kim B. Yancey,Hiroshi Shimizu,Emi K. Nishimura,Emi K. Nishimura,Emi K. Nishimura +16 more
TL;DR: Collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosomal transmembrane collagen, is highly expressed in hair follicle stem cells (HFSCs) and is required for the maintenance not only of HFSCs but also of melanocyte stem cells(MSCs), which do not express Col17a1 but directly adhere to HF SCs.
Journal ArticleDOI
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
TL;DR: It is found that DnMT3a and Dnmt3b function as de novo DNA methyltransferases during differentiation of hematopoietic cells during HSC self-renewal.
Journal ArticleDOI
Adult mouse hematopoietic stem cells: purification and single-cell assays
Hideo Ema,Yohei Morita,Satoshi Yamazaki,Azusa Matsubara,Jun Seita,Yuko Tadokoro,Hiroyoshi Kondo,Hina Takano,Hiromitsu Nakauchi +8 more
TL;DR: Current protocols for the purification of CD34−/lowc-Kit+Sca-1+lineage marker− (CD34−KSL) cells, the HSC population making up approximately 0.005% of bone marrow cells in adult C557BL/6 mice, are described and immunostaining procedures for small numbers of HSCs are introduced, which are useful for signal transduction analysis.
Journal ArticleDOI
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
Yuko Kato,Atsushi Iwama,Yuko Tadokoro,Kazuya Shimoda,Mayu Minoguchi,Shizuo Akira,Minoru Tanaka,Atsushi Miyajima,Toshio Kitamura,Hiromitsu Nakauchi +9 more
TL;DR: Sustained STAT5 activation in CD34–KSL HSCs but not inCD34+KSL multipotential progenitors induced fatal MPD, indicating that the capacity of STAT5 to promote self-renewal of hematopoietic stem cells is crucial to MPD development.