Shintaro Tanimura

TL;DR: It is reported that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice, and deficiency of Ataxia-telangiectasia mutated (ATM), a central transducer kinase of the DNA-damage response, sensitizes MSC's to ectopic differentiation, demonstrating that the kinase protects MSCS from their premature differentiation by functioning as a "stemness checkpoint" to maintain the stem cell quality and quantity

TL;DR: Collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosomal transmembrane collagen, is highly expressed in hair follicle stem cells (HFSCs) and is required for the maintenance not only of HFSCs but also of melanocyte stem cells(MSCs), which do not express Col17a1 but directly adhere to HF SCs.

TL;DR: It is suggested that western blotting using recombinant full‐length type VII collagen could be useful for diagnosis of EBA, and that EBA associated with psoriasis may have a tendency to be the inflammatory type.

TL;DR: Clinically, FSCH is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements that shares several similar features to sebaceous trichofolliculoma but it is usually possible to differentiate these two tumours.