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Yukun Xia
Researcher at Fudan University
Publications - 7
Citations - 235
Yukun Xia is an academic researcher from Fudan University. The author has contributed to research in topics: Phosphorylation & Mutant. The author has an hindex of 6, co-authored 7 publications receiving 179 citations.
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Journal ArticleDOI
Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.
Shiwen Wang,Bowen Jiang,Tengfei Zhang,Lixia Liu,Yi Wang,Yi-Ping Wang,Xiufei Chen,Huaipeng Lin,L Zhou,Yukun Xia,Leilei Chen,Chen Yang,Yue Xiong,Dan Ye,Kun-Liang Guan +14 more
TL;DR: This study uncovers a previously unknown mechanism for the insulin and mTOR pathway in regulation of glycolytic ATP production and cellular redox potential via HDAC3-mediated PGK1 deacetylation.
Journal ArticleDOI
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth
Shenghong Ma,Bowen Jiang,Wanglong Deng,Zhong Kai Gu,Feizhen Wu,Tingting Li,Yukun Xia,Hui Yang,Dan Ye,Yue Xiong,Yue Xiong,Kun-Liang Guan,Kun-Liang Guan +12 more
TL;DR: A new activity of oncometabolite D-2-HG in promoting tumorigenesis is identified, which strongly inhibits anchorage independent growth in vitro and tumor growth in xenografted mouse models.
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SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Mengli Zhang,Jian Wu,Renqiang Sun,Xiaoting Tao,Xiaoxia Wang,Qi Kang,Hui Wang,Lei Zhang,Peng Liu,Jinye Zhang,Yukun Xia,Yuzheng Zhao,Yi Yang,Yue Xiong,Yue Xiong,Kun-Liang Guan,Kun-Liang Guan,Yunzeng Zou,Dan Ye +18 more
TL;DR: It is shown that Sirt5 deficiency leads to suppression of mitochondrial NADH oxidation and inhibition of ATP synthase activity, which uncovers an important role of SIRT5 in regulating cellular energy metabolism and AMPK activation in response to energy stress.
Journal ArticleDOI
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
Xiaoran Han,Zhengyu Zha,Hai-Xin Yuan,Xu Feng,Yukun Xia,Qun-Ying Lei,Qun-Ying Lei,Kun-Liang Guan,Yue Xiong +8 more
TL;DR: A novel function of KDM2B is revealed in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations.
Journal ArticleDOI
Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
Yukun Xia,Yi-Rong Zeng,Mengli Zhang,Peng Liu,Fang Liu,Hao Zhang,Chenxi He,Yi-Ping Sun,Jinye Zhang,Cheng Zhang,Lei Song,Chen Ding,Yu-Jie Tang,Zhen Yang,Chen Yang,Pu Wang,Kun-Liang Guan,Yue Xiong,Dan Ye +18 more
TL;DR: The results suggest that ASXL1 mutations result in neomorphic alleles that contribute to leukemogenesis at least in part through dominantly inhibiting the wild-type AsXL1 from interacting with BAP1 and thereby impairing the function of ASXL 1-BAP1-TF in regulating target genes and leukemia cell growth.