F
Feizhen Wu
Researcher at Fudan University
Publications - 56
Citations - 4714
Feizhen Wu is an academic researcher from Fudan University. The author has contributed to research in topics: DNA methylation & Regulation of gene expression. The author has an hindex of 23, co-authored 46 publications receiving 3701 citations. Previous affiliations of Feizhen Wu include Fudan University Shanghai Medical College & Harvard University.
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Journal ArticleDOI
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
Christine G. Lian,Yufei Xu,Craig J. Ceol,Craig J. Ceol,Feizhen Wu,Allison R. Larson,Karen Dresser,Wenqi Xu,Li Tan,Yeguang Hu,Qian Zhan,Chung-Wei Lee,Di Hu,Bill Q. Lian,Bill Q. Lian,Sonja Kleffel,Yijun Yang,James Neiswender,Abraham J. Khorasani,Rui Fang,Cecilia Lezcano,Lyn M. Duncan,Richard A. Scolyer,John F. Thompson,Hojabr Kakavand,Yariv Houvras,Yariv Houvras,Leonard I. Zon,Martin C. Mihm,Ursula B. Kaiser,Tobias Schatton,Bruce A. Woda,George F. Murphy,Yujiang Geno Shi,Yujiang Geno Shi +34 more
TL;DR: This study reveals a critical function of 5-hmC in melanoma development and directly links the IDH and TET activity-dependent epigenetic pathway to 5-mC-mediated suppression of melanoma progression, suggesting a new strategy for epigenetic cancer therapy.
Journal ArticleDOI
Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells
Yufei Xu,Feizhen Wu,Li Tan,Lingchun Kong,Lijun Xiong,Jie Deng,Andrew J. Barbera,Lijuan Zheng,Haikuo Zhang,Stephen A. Huang,Jinrong Min,Thomas B. Nicholson,Taiping Chen,Guoliang Xu,Yang Shi,Yang Shi,Kun Zhang,Yujiang Geno Shi,Yujiang Geno Shi +18 more
TL;DR: The data suggest that Tet1 controls DNA methylation both by binding to CpG-rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5mC to 5hmC through hydroxylase activity.
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Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu,Di Wu,Di Hu,Di Hu,Hao Chen,Hao Chen,Guo-Ming Shi,Guo-Ming Shi,Irfete S. Fetahu,Feizhen Wu,Feizhen Wu,Kimberlie Rabidou,Rui Fang,Li Tan,Shuyun Xu,Hang Liu,Christian Argueta,Lei Zhang,Fei Mao,Guoquan Yan,Jiajia Chen,Zhao-Ru Dong,Ruitu Lv,Yufei Xu,Mei Wang,Yong Ye,Shike Zhang,Danielle Duquette,Songmei Geng,Clark Yin,Christine G. Lian,George F. Murphy,Gail K. Adler,Rajesh Garg,Lydia Lynch,Pengyuan Yang,Yiming Li,Fei Lan,Jia Fan,Yang Shi,Yang Shi,Yujiang Geno Shi,Yujiang Geno Shi +42 more
TL;DR: A new model for how a pernicious environment can directly reprogram the epigenome towards an oncogenic state is presented, offering a potential strategy for cancer prevention and treatment.
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MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages
TL;DR: MicroRNA-125a-5p may partly provide post-transcriptional regulation of the proinflammatory response, lipid uptake, and expression of ORP9 in oxLDL-stimulated monocyte/macrophages.
Journal ArticleDOI
Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development
Yufei Xu,Chao Xu,Akiko Kato,Wolfram Tempel,José G. Abreu,Chuanbing Bian,Yeguang Hu,Di Hu,Di Hu,Bin Zhao,Tanja Cerovina,Jianbo Diao,Feizhen Wu,Housheng Hansen He,Qingyan Cui,Erin A. Clark,Chun Ma,Chun Ma,Andrew Barbara,Gert Jan C. Veenstra,Guoliang Xu,Ursula B. Kaiser,X. Shirley Liu,Stephen P. Sugrue,Xi He,Jinrong Min,Yoichi Kato,Yujiang Geno Shi +27 more
TL;DR: These findings define Tet3 as a transcription regulator and reveal a molecular mechanism by which the 5mC hydroxylase and DNA binding activities of Tet3 cooperate to control target gene expression and embryonic development.