Yulia Katsman

TL;DR: The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression.

TL;DR: It is revealed that only the distal cluster containing SRR107 and SRR111, located >100 kb downstream from Sox2, is required for cis-regulation of Sox2 in ES cells, and homozygous deletion of this distal Sox2 control region (SCR) caused significant reduction in Sox2 mRNA and protein levels, loss of ES cell colony morphology, genome-wide changes in gene expression, and impaired neuroectodermal formation upon spontaneous differentiation to embryoid bodies.

TL;DR: It is found when using a mouse model of immune thrombocytopenia (ITP) that platelet nadir could not be maintained in the face of daily PLT antibody, making interpretation of treatment modalities difficult.

TL;DR: Evidence is provided that SHP-1 can negatively regulate growth of malignant human T cells and that lack of SHp-1 protein or function may be associated with lymphomagenesis, and the first evidence showing a protein product detectable in cells that is translated from an alternatively spliced form of SHP -1 mRNA is provided.

TL;DR: It is speculated that VT1A may provide a benign approach to reduction of (X4 or R5) HIV cell susceptibility as well as up regulation of 30 genes, suggesting HIV protection via reduced gene activation.