Showing papers in "Experimental Hematology in 2003"

TL;DR: Undifferentiated and differentiated MSC do not elicit alloreactive lymphocyte proliferative responses and modulate immune responses, and the findings support that MSC can be transplantable between HLA-incompatible individuals.

TL;DR: In this review, retrovirus-mediated strategies used for investigation of gene functions and function-based screening strategies are described.

TL;DR: Increasing the sialic acid-containing carbohydrate content beyond the maximum found in EPO leads to a molecule with a longer circulating half-life and thereby an increased in vivo potency that can be administered less frequently.

TL;DR: How inhibition of PARP-1 may enhance the efficiency of cancer therapy is discussed, as well as its role in cancer therapy, irradiation, and chemotherapy, all of which may cause DNA damage and overactivate PARp-1, resulting in inflammation caused by necrosis.

TL;DR: It is suggested that STI571 did not show preferential cytotoxicity to neoplastic human mast cells and thus may not be effective in the treatment of human systemic mastocytosis associated with codon 816 c-kit mutations.

TL;DR: Evidence is marshalled in support of the hypothesis that aging stem cells play a critical role in determining the effects of aging on organ function, and ultimately on the lifespan of a mammal.

TL;DR: Cotransplantation of human mesenchymal stem cells with CD34(+)-selected hematopoietic stem cells enhances myelopoiesis and megakaryocytopoies is enhanced.

TL;DR: The direct proteolytic cleavage of c-KIT by neutrophil and macrophage proteases represents a novel pathway to regulate the levels of c -KIT expression at the surface of hematopoietic cells and may be responsible in part for the down-regulation of c

TL;DR: The migration of donor CD8(+) T cells to GVHD target organs such as the intestine depends on the expression of CXCR3 and contributes significantly to GvHD damage and overall mortality.

TL;DR: Results show that primary mesenchymal cells from fetal lung and BM promote the engraftment of UCB-derived CD34(+) cells to a similar degree as culture-expanded MSC, indicating that it reflects a biological property of primary MSC that is preserved during expansion in culture.

TL;DR: This review will focus on hematopoietic and vascular development in the early mouse embryo and will discuss potential implications of recent studies for stem cell transplantation in humans.

TL;DR: The data demonstrate that although tm-SCF does not appear to play a role in the homing of transplanted cells to the bone marrow, it is critical in the lodgment and detainment of HSC within their hemopoietic "niche."

TL;DR: This approach not only provides an alternative strategy to expand adult BM-derived nonhematopoietic progenitor cell numbers in a scalable and controllable bioprocess, but also questions established biological paradigms concerning the properties of connective-tissue stem and progenitors.

TL;DR: CD26 plays a critical role in G-CSF-induced mobilization of HPC, and peripheral blood cells, bone marrow cells, and spleen cells were assessed forCFU-GM, BFU-E, and CFU-GEMM content.

TL;DR: Characterization of clinical immune responses in patients treated for relapsed leukemia after allogeneic SCT with donor lymphocyte infusion in the absence of GVHD may lead to the characterization of new mHags that can be exploited to generate tumor-specific immune responses.

TL;DR: In this article, a review of the morphological, biochemical, and growth characteristics of these cells, and the results from investigations of the multiple myeloma (MM) are presented.

TL;DR: The data show that co-infusion of a CB unit and a low number of haploidentical CD34+ cells may result in a shortened period of posttransplant neutropenia, likely the result of prompt and transient engraftment of the haploIDENTical hematopoietic stem cells that may provide the patient antimicrobial protection until the later engraftments of the CB hematoplastic stem cells.

TL;DR: The Trp53-null allele expands bone marrow Lin(-)Sca-1(+)c-kit(+)CD34(-) cells and the overall activity of HSCs; however, it increases recipient mortality.

TL;DR: Most T and B lymphocytes express a nai;ve phenotype in cord blood while "suppressor" and "cytotoxic" T-cell subsets are absent, which may represent homeostatic expansion rather than antigen-driven proliferation.

TL;DR: The properties of these phospholipid phosphatases are focused on and recent data showing that the activities of these negative regulators often are modulated by simply altering their protein levels are summarized.

TL;DR: For the first time, it is demonstrated that treating cells with this condition prior to intramuscular injection increased efficiency of engraftment and differentiation in vivo.

TL;DR: The authors' human hTERT-MSCs will be useful for elucidating the mechanism of the formation of CAs and showed a similar doubling time as primary MSCs and continued to proliferate to over 80 population doublings (PD), although the primary M SCs underwent crisis in vitro at 16 PD.

TL;DR: Exogenous growth factors can differentially affect the ability of HSCs to execute a self-renewal division within a single cell cycle even when the kinetics of proliferation are the same.

TL;DR: Continued research by transplant teams worldwide is likely to allow continued progress toward developing novel and improved treatment modalities and even wider application of the use of pluripotent hematopoietic stem cells in the treatment of human diseases.

TL;DR: The immunity of nonmyeloablative HCT recipients appears better than the immunity of conventional H CT recipients early, but not late, after HCT.

TL;DR: The results show that adult CD34+ cells develop into functional CD5+ B cells in NOG spleen as much as fetal CD34- cells do.

TL;DR: Aged BALB mice show hematopoietic and HSC senescence and clonal succession, and Lifelong DR slows hematopolietic senescENCE and prevents HSC aging.

TL;DR: The finding that both CD34(-) andCD34(+) cells from primary/secondary groups engraft secondary/tertiary hosts indicates that CD34 expression on human HSC is reversible, a process that does not impair HSC function in vivo.

TL;DR: The data suggest that although RIC allotransplant induces high rates of CR and near CR, even in refractory disease, it appears to result in a durable response only if it is applied early in the disease in high-risk patients, when they still are chemosensitive and have an adequate PS.

TL;DR: The results of this study support the idea that a balance between cytokines derived from type 1 and type 2 T-helper cells may be important in the development and control of aGVHD.