R
Robert Sugar
Researcher at European Bioinformatics Institute
Publications - 17
Citations - 1823
Robert Sugar is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Mobile agent & Promoter. The author has an hindex of 8, co-authored 17 publications receiving 1520 citations. Previous affiliations of Robert Sugar include Microsoft & Francis Crick Institute.
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Journal ArticleDOI
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud,Filipe Tavares-Cadete,Alice N Young,Robert Sugar,Stefan Schoenfelder,Lauren Ferreira,Steven W. Wingett,Simon Andrews,William Grey,Philip Ewels,Bram Herman,Scott Happe,Andy Higgs,Emily M LeProust,George A. Follows,Peter Fraser,Nicholas M. Luscombe,Cameron S. Osborne +17 more
TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.
Journal ArticleDOI
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Stefan Schoenfelder,Mayra Furlan-Magaril,Borbala Mifsud,Filipe Tavares-Cadete,Filipe Tavares-Cadete,Robert Sugar,Biola M. Javierre,Takashi Nagano,Yulia Katsman,Moorthy Sakthidevi,Steven W. Wingett,Emilia Dimitrova,Andrew Dimond,Lucas Brandon Edelman,Sarah Elderkin,Kristina Tabbada,Elodie Darbo,Elodie Darbo,Simon Andrews,Bram Herman,Andy Higgs,Emily M LeProust,Cameron S. Osborne,Jennifer A. Mitchell,Nicholas M. Luscombe,Nicholas M. Luscombe,Peter Fraser +26 more
TL;DR: The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression.
Journal ArticleDOI
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Stefan Schoenfelder,Robert Sugar,Andrew Dimond,Biola-Maria Javierre,Harry J. Armstrong,Borbala Mifsud,Borbala Mifsud,Emilia Dimitrova,Emilia Dimitrova,Louise S. Matheson,Filipe Tavares-Cadete,Mayra Furlan-Magaril,Anne Segonds-Pichon,Wiktor Jurkowski,Steven W. Wingett,Kristina Tabbada,Simon Andrews,Bram Herman,Emily M LeProust,Cameron S. Osborne,Haruhiko Koseki,Peter Fraser,Nicholas M. Luscombe,Sarah Elderkin +23 more
TL;DR: PRC1 physically constrains developmental transcription factor genes and their enhancers in a silenced but poised spatial network and it is proposed that the selective release of genes from this spatial network underlies cell fate specification during early embryonic development.
Journal ArticleDOI
GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.
Borbala Mifsud,Inigo Martincorena,Elodie Darbo,Robert Sugar,Stefan Schoenfelder,Peter Fraser,Nicholas M. Luscombe,Nicholas M. Luscombe,Nicholas M. Luscombe +8 more
TL;DR: A simple binomial probabilistic model is introduced that resolves complex biases and distinguishes between true and false interactions and provides a statistical framework for further data analysis, such as comparisons of Hi-C interactions between different conditions.
A glove-based gesture interface for wearable computing applications
TL;DR: Preliminary results from user feedback given at a public demonstration of the gesture recognition software and the integration of the device into application software with the help of a context framework are presented.