S
Sarah Elderkin
Researcher at Babraham Institute
Publications - 20
Citations - 2812
Sarah Elderkin is an academic researcher from Babraham Institute. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 16, co-authored 20 publications receiving 2516 citations. Previous affiliations of Sarah Elderkin include Imperial College London & University of Manchester.
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Journal ArticleDOI
RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
Lígia Tavares,Emilia Dimitrova,David Oxley,Judith Webster,Raymond A. Poot,Jeroen Demmers,Karel Bezstarosti,Stephen Taylor,Hiroki Ura,Hiroshi Koide,Anton Wutz,Miguel Vidal,Sarah Elderkin,Neil Brockdorff +13 more
TL;DR: It is shown that RING1B, the catalytic subunit of PRC1, and associated monoubiquitylation of histone H2A are targeted to closely overlapping sites in wild-type and PRC2-deficient mouse embryonic stem cells (mESCs), demonstrating an H3K27me3-independent pathway for recruitment ofPRC1 activity.
Journal ArticleDOI
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Stefan Schoenfelder,Mayra Furlan-Magaril,Borbala Mifsud,Filipe Tavares-Cadete,Filipe Tavares-Cadete,Robert Sugar,Biola M. Javierre,Takashi Nagano,Yulia Katsman,Moorthy Sakthidevi,Steven W. Wingett,Emilia Dimitrova,Andrew Dimond,Lucas Brandon Edelman,Sarah Elderkin,Kristina Tabbada,Elodie Darbo,Elodie Darbo,Simon Andrews,Bram Herman,Andy Higgs,Emily M LeProust,Cameron S. Osborne,Jennifer A. Mitchell,Nicholas M. Luscombe,Nicholas M. Luscombe,Peter Fraser +26 more
TL;DR: The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression.
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Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Stefan Schoenfelder,Robert Sugar,Andrew Dimond,Biola-Maria Javierre,Harry J. Armstrong,Borbala Mifsud,Borbala Mifsud,Emilia Dimitrova,Emilia Dimitrova,Louise S. Matheson,Filipe Tavares-Cadete,Mayra Furlan-Magaril,Anne Segonds-Pichon,Wiktor Jurkowski,Steven W. Wingett,Kristina Tabbada,Simon Andrews,Bram Herman,Emily M LeProust,Cameron S. Osborne,Haruhiko Koseki,Peter Fraser,Nicholas M. Luscombe,Sarah Elderkin +23 more
TL;DR: PRC1 physically constrains developmental transcription factor genes and their enhancers in a silenced but poised spatial network and it is proposed that the selective release of genes from this spatial network underlies cell fate specification during early embryonic development.
Journal ArticleDOI
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.
Sarah Cooper,Martin Dienstbier,Raihann Hassan,Lothar Schermelleh,Jafar Sharif,Neil P. Blackledge,Valeria De Marco,Sarah Elderkin,Haruhiko Koseki,Robert J. Klose,Andreas Heger,Neil Brockdorff +11 more
TL;DR: Surprisingly, it is found thatPRC1-linked H2A monoubiquitylation is sufficient to recruit PRC2 to chromatin in vivo, suggesting a mechanism through which recognition of unmethylated CpG determines the localization of both PRC1 andPRC2 at canonical and atypical target sites.
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Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.
Stephen S. Taylor,Deema Hussein,Yunmei Wang,Yunmei Wang,Sarah Elderkin,Christopher J. Morrow +5 more
TL;DR: BUB1 and BubR1 may integrate different 'spindle assembly signals' into a single signal which can be interpreted by downstream cell cycle regulators, and are part of a common complex during mitosis.