A
Andy Higgs
Researcher at Agilent Technologies
Publications - 3
Citations - 1349
Andy Higgs is an academic researcher from Agilent Technologies. The author has contributed to research in topics: Promoter & Genome. The author has an hindex of 3, co-authored 3 publications receiving 1112 citations.
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Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud,Filipe Tavares-Cadete,Alice N Young,Robert Sugar,Stefan Schoenfelder,Lauren Ferreira,Steven W. Wingett,Simon Andrews,William Grey,Philip Ewels,Bram Herman,Scott Happe,Andy Higgs,Emily M LeProust,George A. Follows,Peter Fraser,Nicholas M. Luscombe,Cameron S. Osborne +17 more
TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.
Journal ArticleDOI
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Stefan Schoenfelder,Mayra Furlan-Magaril,Borbala Mifsud,Filipe Tavares-Cadete,Filipe Tavares-Cadete,Robert Sugar,Biola M. Javierre,Takashi Nagano,Yulia Katsman,Moorthy Sakthidevi,Steven W. Wingett,Emilia Dimitrova,Andrew Dimond,Lucas Brandon Edelman,Sarah Elderkin,Kristina Tabbada,Elodie Darbo,Elodie Darbo,Simon Andrews,Bram Herman,Andy Higgs,Emily M LeProust,Cameron S. Osborne,Jennifer A. Mitchell,Nicholas M. Luscombe,Nicholas M. Luscombe,Peter Fraser +26 more
TL;DR: The results provide the first genome-wide catalog linking gene promoters to their long-range interacting elements and highlight the complex spatial regulatory circuitry controlling mammalian gene expression.
Journal ArticleDOI
A novel method for the genome-wide high resolution analysis of DNA damage
Yumin Teng,Mark Bennett,Katie Ellen Evans,Huayun Zhuang-Jackson,Andy Higgs,Simon H. Reed,Raymond Waters +6 more
TL;DR: A new development based on microarray technology is described which uses ultraviolet light induced DNA damage as a paradigm to determine the position and frequency of DNA damage and its subsequent repair throughout the entire yeast genome.