Y
Yun Li
Researcher at Chinese Academy of Sciences
Publications - 38
Citations - 788
Yun Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Influenza A virus. The author has an hindex of 13, co-authored 31 publications receiving 559 citations. Previous affiliations of Yun Li include University of Pennsylvania & Children's Hospital of Philadelphia.
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Journal ArticleDOI
Comparison between luminescence and radiocarbon dating of late Quaternary loess from the Ili Basin in Central Asia
TL;DR: In this article, the authors established a closely spaced quartz optically stimulated luminescence (OSL) chronology for the 20.5m-thick Nilka loess section in the Ili Basin in Central Asia.
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FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid.
Elliot S. Friedman,Yun Li,Ting-Chin David Shen,Jack Jiang,Lillian Chau,Luciano Adorini,Farah Babakhani,Jeffrey E. Edwards,David Shapiro,Chunyu Zhao,Rotonya M. Carr,Kyle Bittinger,Hongzhe Li,Gary D. Wu +13 more
TL;DR: Evidence for interactions between bile acids and features of the small intestinal microbiome is found and indicates that farnesoid X receptor activation alters the intestinal microbiota and could provide opportunities for microbiome biomarker discovery or new approaches to engineering the human microbiome.
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An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy
Yun Li,Jason A. Chen,Renee L. Sears,Fuying Gao,Eric Klein,Anna Karydas,Michael D. Geschwind,Howard J. Rosen,Adam L. Boxer,Weilong Guo,Matteo Pellegrini,Steve Horvath,Bruce L. Miller,Daniel H. Geschwind,Giovanni Coppola +14 more
TL;DR: Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls, indicating a mediating role for methylation in dementia pathophysiology.
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Dynamic modular architecture of protein-protein interaction networks beyond the dichotomy of ‘date’ and ‘party’ hubs
TL;DR: This study evaluated two data sets of yeast interactome, and systematically investigated the behavior of hubs from multiple perspectives including co-expression patterns, topological roles and functional classifications, confirming the presence of hub dichotomy.
Journal ArticleDOI
Bacterial colonization reprograms the neonatal gut metabolome.
Kyle Bittinger,Chunyu Zhao,Yun Li,Eileen G Ford,Elliot S. Friedman,Josephine Ni,Chiraag Kulkarni,Jingwei Cai,Yuan Tian,Qing Liu,Andrew D. Patterson,Debolina Sarkar,Siu Hung Joshua Chan,Costas D. Maranas,Anumita Saha-Shah,Peder J. Lund,Benjamin A. Garcia,Lisa M. Mattei,Jeffrey S. Gerber,Michal A. Elovitz,Andrea Kelly,Patricia A. DeRusso,Dorothy Kim,Casey E. Hofstaedter,Mark Goulian,Hongzhe Li,Frederic D. Bushman,Babette S. Zemel,Gary D. Wu +28 more
TL;DR: It is shown that the gut is detectably colonized within 16 h of birth, with Escherichia coli dominating, and that this correlates with proteome and metabolome changes including the fermentation of amino acids, which provides a mechanism for the initial growth of E. coli under anaerobic conditions.