C
Costas D. Maranas
Researcher at Pennsylvania State University
Publications - 279
Citations - 18822
Costas D. Maranas is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Metabolic network & Biology. The author has an hindex of 52, co-authored 256 publications receiving 16371 citations. Previous affiliations of Costas D. Maranas include Oak Ridge National Laboratory & Princeton University.
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Journal ArticleDOI
OptKnock: A Bilevel Programming Framework for Identifying Gene Knockout Strategies for Microbial Strain Optimization
TL;DR: The computational OptKnock framework is introduced for suggesting gene deletion strategies leading to the overproduction of chemicals or biochemicals in E. coli, and hints at a growth selection/adaptation system for indirectly evolving overproducing mutants.
Journal ArticleDOI
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0
Laurent Heirendt,Sylvain Arreckx,Thomas Pfau,Sebastián N. Mendoza,Anne Richelle,Almut Heinken,Hulda S. Haraldsdóttir,Jacek Wachowiak,Sarah M. Keating,Vanja Vlasov,Stefania Magnusdottir,Chiam Yu Ng,German Preciat,Alise Žagare,Siu Hung Joshua Chan,Maike K. Aurich,Catherine M. Clancy,Jennifer Modamio,John T. Sauls,Alberto Noronha,Aarash Bordbar,Benjamin Cousins,Diana C. El Assal,Luis Vitores Valcárcel,Iñigo Apaolaza,Susan Ghaderi,Masoud Ahookhosh,Marouen Ben Guebila,Andrejs Kostromins,Nicolas Sompairac,Hoai M. Le,Ding Ma,Yuekai Sun,Lin Wang,James T. Yurkovich,Miguel A.P. Oliveira,Phan Tu Vuong,Lemmer P. El Assal,Inna Kuperstein,Andrei Zinovyev,H. Scott Hinton,William A. Bryant,Francisco J. Aragón Artacho,Francisco J. Planes,Egils Stalidzans,Alejandro Maass,Santosh Vempala,Michael Hucka,Michael A. Saunders,Costas D. Maranas,Nathan E. Lewis,Thomas Sauter,Bernhard O. Palsson,Bernhard O. Palsson,Ines Thiele,Ronan M. T. Fleming,Ronan M. T. Fleming +56 more
TL;DR: This protocol provides an overview of all new features of the COBRA Toolbox and can be adapted to generate and analyze constraint-based models in a wide variety of scenarios.
Journal ArticleDOI
Managing demand uncertainty in supply chain planning
Anshuman Gupta,Costas D. Maranas +1 more
TL;DR: A stochastic programming based approach is described to model the planning process as it reacts to demand realizations unfolding over time, which provides an effective tool for evaluating and actively managing the exposure of an enterprises assets to market uncertainties.
Journal ArticleDOI
OptStrain: A computational framework for redesign of microbial production systems
TL;DR: OptStrain provides a useful tool to aid microbial strain design and, more importantly, it establishes an integrated framework to accommodate future modeling developments by establishing an integrated computational framework capable of constructing stoichiometrically balanced pathways.
Journal ArticleDOI
αBB: A global optimization method for general constrained nonconvex problems
TL;DR: The proposed branch and bound type algorithm attains finiteε-convergence to the global minimum through the successive subdivision of the original region and the subsequent solution of a series of nonlinear convex minimization problems.