YuShan Tu

TL;DR: The findings demonstrate the existence of sexually dimorphic pain signalling in rats, suggesting that this sex difference is evolutionarily conserved, at least across rodent species.

TL;DR: It is shown that circulating activators of NOD1, a receptor for bacterial peptidoglycan, increase with high fat feeding in mice, suggesting that N OD1 could be a critical sensor leading to metabolic inflammation.

TL;DR: Neonatal microglial inhibition with systemic minocycline or intrathecal SB203580 at the time of neonatal incision revealed sex-dependent effects: the persistent mechanical and thermal hyperalgesia following reincision in adulthood was prevented in males but unaffected in females, emphasizing the importance of evaluating sex- dependent differences at all ages in preclinical studies.

TL;DR: Alternative splicing of GluN1 is a mechanism for controlling physiological long-lasting synaptic potentiation, learning, and memory and in human iPSC-derived neurons in autism spectrum disorder NMDARs show characteristics of N1-lacking GLUN1.

TL;DR: These findings provide a basis for utilizing human iPSC-derived neurons in screening for drugs targeting NMDARs in neurological disorders, and are the first evidence that tyrosine phosphorylation regulates the function of NMD ARs in human i PSCs.