Yutong Liu

TL;DR: High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

TL;DR: Over 100 structure-guided spike variants based upon a previously determined cryo-EM structure of the prefusion SARS-CoV-2 spike are designed and expressed, with the best variant, HexaPro, having six beneficial proline substitutions leading to ∼10-fold higher expression than its parental construct.

TL;DR: In this article , the human IgG1 Fc domain was used to enhance pH-selective binding to the receptor FcγRIIIa and subsequent antibody-dependent cellular cytotoxicity (ADCC).

TL;DR: In this article , the authors discuss recent efforts to develop advanced antibody therapeutics with activities restricted to the solid tumor microenvironment, with the intent of decreasing toxicities and expanding therapeutic windows, protein engineering strategies can render ligand binding sensitive to multiple tumor-specific characteristics.

TL;DR: The identified bound cofactors and structural features that are associated with SARS-CoV-1 S locked conformations are identified and newly determined structures are compared to other available spike structures of Sarbecoviruses to identify conserved features and discuss their possible functions.