J
Jennifer A. Maynard
Researcher at University of Texas at Austin
Publications - 89
Citations - 3721
Jennifer A. Maynard is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 26, co-authored 77 publications receiving 2699 citations. Previous affiliations of Jennifer A. Maynard include University of Minnesota & Howard Hughes Medical Institute.
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Journal ArticleDOI
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jason J. Lavinder,Gregory C. Ippolito,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +23 more
TL;DR: High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Journal ArticleDOI
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.
Jennifer A. Maynard,Catharina B.M. Maassen,Stephen H. Leppla,Kathleen M. Brasky,Jean L. Patterson,Brent L. Iverson,George Georgiou +6 more
TL;DR: In vitro, post-challenge protection of macrophages from the action of the holotoxin correlated with the Kd of the scFv variants, and strong correlations among antibody construct affinity, serum half-life, and protection were also observed in a rat model of toxin challenge.
Posted ContentDOI
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia-Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +21 more
TL;DR: Over 100 structure-guided spike variants based upon a previously determined cryo-EM structure of the prefusion SARS-CoV-2 spike are designed and expressed, with the best variant, HexaPro, having six beneficial proline substitutions leading to ∼10-fold higher expression than its parental construct.
Journal ArticleDOI
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Dan Feng,Christopher J. Bond,Lauren Kate Ely,Jennifer A. Maynard,Jennifer A. Maynard,K. Christopher Garcia +5 more
TL;DR: Four TCR–I-A complexes with structurally superimposable interactions between the Vβ loops and the I-A α-helix are found, demonstrating what is probably one of many germline-derived TCR-MHC interaction 'codons'.
Journal ArticleDOI
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Jennifer A. Maynard,Karin Petersson,Dianne H. Wilson,Erin J. Adams,Sylvie E. Blondelle,Marty J. Boulanger,Darcy B. Wilson,K. Christopher Garcia +7 more
TL;DR: It is suggested that while TCR scanning of pMHC may be degenerate due to the TCR germline bias for MHC, recognition of structurally distinct agonist peptides is not indicative of TCR promiscuity, but rather highly specific alternative solutions to TCR engagement.