K
Kamyab Javanmardi
Researcher at University of Texas at Austin
Publications - 21
Citations - 1628
Kamyab Javanmardi is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 8, co-authored 18 publications receiving 681 citations.
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Journal ArticleDOI
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jason J. Lavinder,Gregory C. Ippolito,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +23 more
TL;DR: High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Posted ContentDOI
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia-Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +21 more
TL;DR: Over 100 structure-guided spike variants based upon a previously determined cryo-EM structure of the prefusion SARS-CoV-2 spike are designed and expressed, with the best variant, HexaPro, having six beneficial proline substitutions leading to ∼10-fold higher expression than its parental construct.
Journal ArticleDOI
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.
William N. Voss,Yixuan J. Hou,Nicole V. Johnson,George Delidakis,Jin Eyun Kim,Kamyab Javanmardi,Andrew P. Horton,Foteini Bartzoka,Chelsea J. Paresi,Yuri Tanno,Chia Wei Chou,Shawn A. Abbasi,Whitney Pickens,Katia George,Daniel R. Boutz,Dalton M Towers,Jonathan R. McDaniel,Daniel Billick,Jule Goike,Lori A. Rowe,Lori A. Rowe,Dhwani Batra,Jan Pohl,Justin S. Lee,Shivaprakash Gangappa,Suryaprakash Sambhara,Michelle Gadush,Nianshuang Wang,Maria D. Person,Brent L. Iverson,Jimmy Gollihar,Jimmy Gollihar,John M. Dye,Andrew S. Herbert,Ilya J. Finkelstein,Ralph S. Baric,Jason S. McLellan,George Georgiou,Jason J. Lavinder,Gregory C. Ippolito,Gregory C. Ippolito +40 more
TL;DR: The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.
Journal ArticleDOI
Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area.
S. Wesley Long,S. Wesley Long,Randall J. Olsen,Randall J. Olsen,Paul A. Christensen,David W. Bernard,David W. Bernard,James J. Davis,James J. Davis,Maulik Shukla,Maulik Shukla,Marcus Nguyen,Marcus Nguyen,Matthew Ojeda Saavedra,Prasanti Yerramilli,Layne Pruitt,Sishir Subedi,Hung-Che Kuo,Heather Hendrickson,Ghazaleh Eskandari,Hoang A. T. Nguyen,J. Hunter Long,Muthiah Kumaraswami,Jule Goike,Daniel R. Boutz,Jimmy Gollihar,Jimmy Gollihar,Jason S. McLellan,Chia Wei Chou,Kamyab Javanmardi,Ilya J. Finkelstein,James M. Musser,James M. Musser +32 more
TL;DR: This report provides the first molecular characterization of SARS-CoV-2 strains causing two distinct COVID-19 disease waves, and sequenced the genomes of 5,085 Sars- CoV- 2 strains from these two waves.
Posted ContentDOI
Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
Scott Wesley Long,Randall J. Olsen,Paul A. Christensen,David W. Bernard,James J. Davis,Maulik Shukla,Marcus Nguyen,Matthew Ojeda Saavedra,Prasanti Yerramilli,Layne Pruitt,Sishir Subedi,Hung-Che Kuo,Heather Hendrickson,Ghazaleh Eskandari,Hoang A. T. Nguyen,James Hunter Long,Muthiah Kumaraswami,Jule Goike,Daniel R. Boutz,Jimmy Gollihar,Jason S. McLellan,Chia-Wei Chou,Kamyab Javanmardi,Ilya J. Finkelstein,James M. Musser +24 more
TL;DR: This study is the first analysis of the molecular architecture of SARS-CoV-2 in two infection waves in a major metropolitan region, and exploited the genomic data to generate defined single amino acid replacements in the receptor binding domain of spike protein that produced decreased recognition by the neutralizing monoclonal antibody CR30022.