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Yves Eeckhout
Researcher at Université catholique de Louvain
Publications - 62
Citations - 4738
Yves Eeckhout is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Collagenase & Matrix metalloproteinase. The author has an hindex of 35, co-authored 62 publications receiving 4674 citations. Previous affiliations of Yves Eeckhout include Pasteur Institute & International Institute of Minnesota.
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Journal ArticleDOI
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Peter Carmeliet,Lieve Moons,Roger Lijnen,Myriam Baes,Vincent Lemaître,Peter G. Tipping,Angela Drew,Angela Drew,Yves Eeckhout,Steve Shapiro,Florea Lupu,Desire Collen +11 more
TL;DR: Analysis of atherosclerotic aorta in mice with a deficiency of apoliprotein E indicated that deficiency of u-PA protected against media destruction and aneurysm formation, probably by means of reduced plasmin-dependent activation of pro-MMPs.
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Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation.
Yves Eeckhout,Gilbert Vaes +1 more
TL;DR: It is proposed that cathepsin B, kallikrein and plasmin may play a role in the physiological activation of latent collagenase and thus initiate degradation of collagen in vivo.
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In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.
Jean-Marie Delaissé,Jean-Marie Delaissé,Yves Eeckhout,Yves Eeckhout,Gilbert Vaes,Gilbert Vaes +5 more
TL;DR: Results provide evidence that cysteine proteinases, possibly lysosomal cathepsins, are necessary for bone resorption.
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Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants
TL;DR: It is suggested that progesterone restrains endometrial tissue breakdown by blocking the secretion and activation of MMPs, and almost totally abolished the release of collagenase, of total gelatinase activity, and of the active form of gelatinase B.
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The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts.
Jean-Marie Delaissé,Alan Boyde,E. Maconnachie,N.N. Ali,Christopher H.J. Sear,Yves Eeckhout,Gilbert Vaes,Sheila J. Jones +7 more
TL;DR: The numbers, depths and volumes (but not the plan-areas) of the resorption pits in dentine were significantly reduced by Z-Phe-Ala-CHN2 and E-64, and the volumes and the depths were smaller in these experimental groups compared with control dentine specimens.