Zachary M. Grinspan

TL;DR: This study evaluates early and sustained response to initial treatments and addresses both clinical remission and electrographic resolution of hypsarrhythmia in infants with infantile spasms.

TL;DR: Results suggest that although mossy fibre synapses on to pyramidal cells are associated with a larger number of release sites per synapse, the higher connectivity, higher initial release probability, and larger relative impact per quantum on to CA3 interneurones generate strong feedforward inhibition at physiological firing frequencies of dentate granule cells.

TL;DR: Cholinergic specializations are present within anatomically distinct subpopulations of hippocampal interneurones, suggesting that there may be organizing principles to cholinergic control of GABA release in the hippocampus.

TL;DR: Thorough genetic investigation emphasizing sequencing tests should be incorporated into the initial evaluation of newly presenting early-life epilepsies and not just reserved for those with severe presentations and poor outcomes.

TL;DR: Many areas of health IT application remain understudied and the majority of studies have non-significant or mixed findings, which suggests that larger, higher quality studies need to be conducted, particularly in the long-term care and ambulatory care settings.