Edward J. Novotny

TL;DR: In this paper, a screen for de novo mutations in patients with two classical epileptic encephalopathies: infantile spasms and Lennox-Gastaut syndrome (n = 115) was performed.

TL;DR: Brain lactate concentration is detected during physiologic photic stimulation in human visual cortex with results consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.

TL;DR: 13C isotopic tracer data previously obtained by 13C nuclear magnetic resonance in the human brain in vivo were analyzed using a mathematical model to determine metabolic rates in a region of the human neocortex and the calculated values were found to be unchanged as long as the assumptions remained near reported physiological values.

TL;DR: It is found that temporal lobe seizures associated with loss of consciousness produced CBF increases in the temporal lobe, followed by increases in bilateral midline subcortical structures, which suggest that impaired consciousness in temporal lobe epileptic seizures may result from focal abnormal activity in temporal and subCortical networks linked to widespread impaired function of the association cortex.

TL;DR: In this article, the authors acquired simultaneous EEG-fMRI in 88 typical childhood absence seizures from nine pediatric patients and investigated behavior concurrently using a continuous performance task or simpler repetitive tapping task.