Zening Wang

TL;DR: When overexpressing MMP14 in the early-stage obese adipose tissue, the transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and inflammation, as well as improved lipid and glucose metabolism, which is likely due to digestion/modification of the dense adiposity tissue extracellular matrix by MMP 14, thereby releasing the mechanical stress to allow for its healthy expansion.

TL;DR: Findings identify a negative regulator of GFRAL for the control of non-homeostatic body weight regulation, provide mechanistic insights into the regulation of GDF15 sensitivity, highlight negative regulators of the GDF 15-GFRAL pathway as a therapeutic avenue against obesity and identify MT1-MMP as a promising target.

TL;DR: In this article , the authors identify Membrane-type 1 Matrix Metalloproteinase (MT1-MMP) as a critical host protease for solACE2-mediated SARS-CoV-2 infection.

TL;DR: In this paper , the authors identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of insulin sensitivity during ageing.

TL;DR: In this article , the authors explored the therapeutic potential of a human IgG monoclonal antibody (mAb), L13, which was recently developed with exclusive neutralizing specificity to MMP-9, nanomolar potency and biological function, using mouse stroke models and stroke patient samples.