Junlei Chang

TL;DR: Through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy is reported utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3–1.4 micrometre near-infrared window, providing real-time assessment of blood flow anomaly in a mouse middle cerebral artery occlusion stroke model.

TL;DR: This functionally non-equivalent yet cooperative interaction between Wnt and RSPO ligands establishes a molecular precedent for regulation of mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precise control of tissue regeneration.

TL;DR: It is shown that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels, and it is proposed that this signaling coordinates OPC migration with differentiation.

TL;DR: In this paper, a single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500-1700 nm, NIR-IIb).

TL;DR: It is found that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expresses IL- 1β, who lack these characteristics.