Li Yang

TL;DR: When overexpressing MMP14 in the early-stage obese adipose tissue, the transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and inflammation, as well as improved lipid and glucose metabolism, which is likely due to digestion/modification of the dense adiposity tissue extracellular matrix by MMP 14, thereby releasing the mechanical stress to allow for its healthy expansion.

TL;DR: It is demonstrated that transient overexpression of VEGF-A activates the sympathetic nervous system, which hence promotes lipolysis and browning in adipose tissue and is abolished upon treatment with the β3-adrenoceptor antagonist SR59230A.

TL;DR: A lipolytic signaling induced by Ces3 is highlighted as a unique process to regulate thermogenesis in adipose tissue upon cold exposure by liquid chromatography—tandem mass spectrometry.

TL;DR: It is reported that DRP1 translocates to endoplasmic reticulum (ER) in response to β‐adrenergic stimulation and the alteration of LD dynamics, combined with abnormal mitochondrial and autophagy functions in adipose tissue, ultimately lead to abnormalities in lipid metabolism in Adipo‐Drp1flx/flx mice.

TL;DR: A modified immunofluorescent approach that efficiently co-stains blood vessels and nerve fibers in adipose tissues is described that provides a useful tool for investigating adipose tissue remodeling.