Z
Zhanni Gu
Researcher at Chinese Academy of Sciences
Publications - 8
Citations - 2186
Zhanni Gu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: AMPK & Phosphorylation. The author has an hindex of 6, co-authored 8 publications receiving 1653 citations. Previous affiliations of Zhanni Gu include China Pharmaceutical University.
Papers
More filters
Journal ArticleDOI
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou,Jiang Wang,Zhanni Gu,Shuni Wang,Wei Zhu,José Luis Aceña,Vadim A. Soloshonok,Kunisuke Izawa,Hong Liu +8 more
TL;DR: Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.
Journal ArticleDOI
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
Wei Zhu,Jiang Wang,Shuni Wang,Zhanni Gu,José Luis Aceña,Kunisuke Izawa,Hong Liu,Vadim A. Soloshonok,Vadim A. Soloshonok +8 more
TL;DR: A brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF 3 -containing pharmaceuticals is provided in this paper.
Journal ArticleDOI
Fluorescent Coumarin–Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities
Xu Zhang,Xu Zhang,Qian Ba,Zhanni Gu,Zhanni Gu,Diliang Guo,Diliang Guo,Yu Zhou,Yungen Xu,Hui Wang,Deju Ye,Hong Liu,Hong Liu +12 more
TL;DR: The potential of using mitochondria-targeting fluorophores to selectively trigger and directly visualize subcellular drug delivery in living cells is highlighted.
Journal ArticleDOI
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Rui Zhang,Heng Li,Xianglei Zhang,Jian Li,Haixia Su,Qiukai Lu,Dong Guangyu,Hui-Xia Dou,Chen Fan,Zhanni Gu,Qianwen Mu,Wei Tang,Yechun Xu,Hong Liu +13 more
TL;DR: A series of novel tetrahydroisoquinoline derivatives were developed based on the crystal structure of PDE4D in complex with compound 1, and an in vivo study demonstrated that a topical administration of 36 achieved more significant efficacy than calcipotriol to improve the features of psoriasis-like skin inflammation.
Journal ArticleDOI
Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.
Shengbin Zhou,Yanan Duan,Jiang Wang,Jin Zhang,Haifeng Sun,Haowen Jiang,Zhanni Gu,Junhua Tong,Jing-Ya Li,Jia Li,Hong Liu +10 more
TL;DR: A series of novel berberine derivatives, 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines was designed, synthesized, and biologically evaluated for their anti-diabetic activity.