Zhe Liang

TL;DR: It is shown that 6mA is extensively present in the human genome, and 881,240 6mA sites accounting for ∼0.051% of the total adenines are cataloged, and [G/C]AGG[C/T] was the most significantly associated motif with 6mA modification.

TL;DR: The first genome-wide analysis of the whole MYB superfamily in a legume species, soybean, including the gene structures, phylogeny, chromosome locations, conserved motifs, and expression patterns, as well as a comparative genomic analysis with Arabidopsis reveals that MYB genes play conserved and various roles in plants, which is indicative of a divergence in function.

TL;DR: It is demonstrated that FKBP12 INTERACTING PROTEIN 37 KD (FIP37) is a core component of the m(6)A methyltransferase complex, which underlies control of shoot stem cell fate in Arabidopsis and suggests an indispensable role of FIP37 in mediating m( 6)A mRNA modification, which is required for maintaining the shoot meristem as a renewable source for continuously producing all aerial organs in plants.

TL;DR: Global profiling of 6mA sites at single-nucleotide resolution in the genome of Arabidopsis thaliana at different developmental stages using single-molecule real-time sequencing uncovers 6mA as a DNA mark associated with actively expressed genes inArabidopsis, suggesting that 6mA serves as a hitherto unknown epigenetic mark in land plants.

TL;DR: The results suggest that m5C in mRNA is a new epitranscriptome marker in Arabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development.