Z
Zhen Shi
Researcher at Genentech
Publications - 20
Citations - 1580
Zhen Shi is an academic researcher from Genentech. The author has contributed to research in topics: Gene silencing & Translation (biology). The author has an hindex of 12, co-authored 18 publications receiving 1196 citations. Previous affiliations of Zhen Shi include Harvard University & Tsinghua University.
Papers
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Journal ArticleDOI
Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide
Zhen Shi,Kotaro Fujii,Kyle M. Kovary,Naomi R. Genuth,Hannes L. Röst,Mary N. Teruel,Maria Barna +6 more
TL;DR: It is found that heterogeneity in RP composition endows ribosomes with differential selectivity for translating subpools of transcripts, including those controlling metabolism, cell cycle, and development.
Journal ArticleDOI
Differential Requirements for eIF4E Dose in Normal Development and Cancer
Morgan L. Truitt,Crystal S. Conn,Zhen Shi,Xiaming Pang,Taku Tokuyasu,Alison Coady,Youngho Seo,Maria Barna,Davide Ruggero +8 more
TL;DR: It is demonstrated that the dose of eIF4E is essential for translating mRNAs that regulate reactive oxygen species, fueling transformation and cancer cell survival in vivo, and also for driving a translational program supporting tumorigenesis.
Journal ArticleDOI
Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins
Zhen Shi,Maria Barna +1 more
TL;DR: Understanding this largely unexplored world of translational codes hardwired in the core translation machinery is an exciting new research frontier fundamental to the understanding of gene regulation, organismal development and evolution.
Journal ArticleDOI
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Yichen Xu,Mauro Poggio,Hyun Yong Jin,Zhen Shi,Craig M. Forester,Ying Wang,Ying Wang,Craig R. Stumpf,Lingru Xue,Emily Devericks,Lomon So,Hao G. Nguyen,Alice Griselin,John D. Gordan,Sarah E. Umetsu,Reich Siegfried Heinz,Stephen T. Worland,Saurabh Asthana,Maria Barna,Kevin R. Webster,John T. Cunningham,John T. Cunningham,Davide Ruggero +22 more
TL;DR: An in vivo mouse model of liver cancer is developed to study oncogene cooperation in immunosurveillance and reveals how immune-checkpoint proteins are manipulated by distinct oncogenes at the level of mRNA translation, which can be exploited for new immunotherapies.
Journal ArticleDOI
SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.
TL;DR: It is shown that the synthesis of β‐catenin protein, which requires a group of serine/arginine‐rich splicing factors (SRSF), also contributes to its tumorigenic activity and that a combinational therapy could be a promising approach for the treatment of cancer patients.