Taku Tokuyasu

TL;DR: It is shown that the recurrent CNAs differ between tumor subtypes defined by expression pattern and that stratification of patients according to outcome can be improved by measuring both expression and copy number, especially high-level amplification.

TL;DR: A fully automatic system for microarray image quantification that automatically locates both subarray grids and individual spots, requiring no user identification of any image coordinates, and yields more accurate estimates of ratios than systems assuming spot circularity.

TL;DR: In this article, the authors applied array comparative genomic hybridization (CGH) to the analysis of breast tumors and found that shorter telomeres and altered telomere related gene expression are associated with amplification.

TL;DR: It is demonstrated that the dose of eIF4E is essential for translating mRNAs that regulate reactive oxygen species, fueling transformation and cancer cell survival in vivo, and also for driving a translational program supporting tumorigenesis.

TL;DR: Findings support the role of c-Met in survival in hypoxia and invasion, features associated with antiangiogenic therapy resistance, and growth and therapeutic resistance of xenografts resistant to antiangIogenic therapy.