C
Crystal S. Conn
Researcher at University of California, San Francisco
Publications - 17
Citations - 1009
Crystal S. Conn is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Translation (biology) & Protein biosynthesis. The author has an hindex of 10, co-authored 16 publications receiving 744 citations. Previous affiliations of Crystal S. Conn include Cornell University & University of California.
Papers
More filters
Journal ArticleDOI
Differential Requirements for eIF4E Dose in Normal Development and Cancer
Morgan L. Truitt,Crystal S. Conn,Zhen Shi,Xiaming Pang,Taku Tokuyasu,Alison Coady,Youngho Seo,Maria Barna,Davide Ruggero +8 more
TL;DR: It is demonstrated that the dose of eIF4E is essential for translating mRNAs that regulate reactive oxygen species, fueling transformation and cancer cell survival in vivo, and also for driving a translational program supporting tumorigenesis.
Journal ArticleDOI
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Feven Tameire,Ioannis I. Verginadis,Nektaria Maria Leli,Christine Polte,Crystal S. Conn,Rani Ojha,Carlo Salas Salinas,Frank Chinga,Alexandra M Monroy,Weixuan Fu,Paul P. Wang,Andrew V. Kossenkov,Jiangbin Ye,Ravi K. Amaravadi,Zoya Ignatova,Serge Y. Fuchs,J. Alan Diehl,Davide Ruggero,Constantinos Koumenis +18 more
TL;DR: An essential role is revealed for activating transcription factor 4 (ATF4) in survival following MYC activation, which establishes ATF4 as a cellular rheostat of MYC activity, which ensures that enhanced translation rates are compatible with survival and tumour progression.
Journal ArticleDOI
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
Dana Gwinn,Dana Gwinn,Alexander Lee,Alexander Lee,Marcela Briones-Martin-del-Campo,Crystal S. Conn,David R. Simpson,David R. Simpson,Anna I Scott,Anthony Le,Tina M. Cowan,Davide Ruggero,E. Alejandro Sweet-Cordero,E. Alejandro Sweet-Cordero +13 more
TL;DR: Inhibition of AKT suppressed ASNS expression and, combined with depletion of extracellular asparagine, decreased tumor growth, and ASNS represents a promising therapeutic target in KRAS mutant NSCLC.
Journal ArticleDOI
Development of a stress response therapy targeting aggressive prostate cancer.
Hao G. Nguyen,Crystal S. Conn,Yae Kye,Lingru Xue,Craig M. Forester,Janet E. Cowan,Andrew C. Hsieh,John T. Cunningham,Charles Truillet,Feven Tameire,Michael J. Evans,Christopher P. Evans,Joy C. Yang,Byron Hann,Constantinos Koumenis,Peter Walter,Peter R. Carroll,Davide Ruggero +17 more
TL;DR: Using murine and humanized models of prostate cancer (PCa), it is shown that one of the three branches of the unfolded protein response is selectively activated in advanced PCa and selectively triggers cytotoxicity against aggressive metastatic PCa.
Journal ArticleDOI
Nutrient Signaling in Protein Homeostasis: An Increase in Quantity at the Expense of Quality
Crystal S. Conn,Shu-Bing Qian +1 more
TL;DR: The results reveal a mechanistic connection between mTORC1 and protein quality, highlighting the central role of nutrient signaling in growth and aging and suggest that rapamycin may exert its effects in part by enhancing the quality of protein synthesis.