Z
Zhenyuan Dong
Researcher at City of Hope National Medical Center
Publications - 20
Citations - 403
Zhenyuan Dong is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Antigen & Virus. The author has an hindex of 10, co-authored 14 publications receiving 323 citations. Previous affiliations of Zhenyuan Dong include Beckman Research Institute & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Targeting myeloid-derived suppressor cells for cancer immunotherapy.
Yijun Liu,Guowei Wei,Wesley A. Cheng,Zhenyuan Dong,Han Sun,Vincent Y. Lee,Soung Chul Cha,D. Lynne Smith,Larry W. Kwak,Hong Qin +9 more
TL;DR: The number of MDSCs positively correlates with protumoral activity, and often diminishes the effectiveness of immunotherapies, which is particularly problematic with the emergence of personalized medicine.
Journal ArticleDOI
Visualizing influenza virus infection in living mice
Weiqi Pan,Zhenyuan Dong,Feng Li,Feng Li,Weixu Meng,Weixu Meng,Liqiang Feng,Xuefeng Niu,Chufang Li,Qinfang Luo,Zhengfeng Li,Caijun Sun,Ling Chen,Ling Chen +13 more
TL;DR: This work reports the visualization of influenza viral infection in living mice using an engineered replication-competent influenza A virus carrying luciferase reporter gene to enable real-time study of influenza virus infection and effects of antiviral therapeutics in living animals.
Journal ArticleDOI
CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies
Hong Qin,Zhenyuan Dong,Xiuli Wang,Wesley A. Cheng,Feng Wen,Feng Wen,Weili Xue,Weili Xue,Han Sun,Miriam Walter,Guowei Wei,D. Lynne Smith,Xiuhua Sun,Fan Fei,Jianming Xie,Theano I. Panagopoulou,Chun-Wei Chen,Joo Y. Song,Ibrahim Aldoss,Clarisse Kayembe,Luisa Sarno,Markus Müschen,Giorgio Inghirami,Stephen J. Forman,Larry W. Kwak +24 more
TL;DR: Humanized, second-generation CAR T cells were developed against another B cell–specific marker, B cell activating factor receptor (BAFF-R), which demonstrated cytotoxicity against human lymphoma and acute lymphoblastic leukemia lines and demonstrated antitumor effects against an additional CD19 antigen loss primary patient–derived xenograft (PDX) in vivo.
Journal ArticleDOI
Generation of replication-competent recombinant influenza A viruses carrying a reporter gene harbored in the neuraminidase segment
TL;DR: It is demonstrated that two recombinant influenza A viruses with a neuraminidase segment harboring enhanced green fluorescent protein (EGFP) in the background of A/PR/8/34 (PR8) were generated and could replicate in noncomplementary cells and propagate to large quantities while maintaining genome stability after multiple passages in embryonated eggs.
Journal ArticleDOI
Novel BAFF-Receptor Antibody to Natively Folded Recombinant Protein Eliminates Drug-Resistant Human B-cell Malignancies In Vivo.
Hong Qin,Guowei Wei,Ippei Sakamaki,Zhenyuan Dong,Wesley A. Cheng,D. Lynne Smith,Feng Wen,Feng Wen,Han Sun,Kunhwa Kim,Soung-chul Cha,Laura Bover,Sattva S. Neelapu,Larry W. Kwak +13 more
TL;DR: It is proposed that these antibodies represent an effective new strategy for targeting and treating drug-resistant B-cell malignancies and warrant further development.