Z
Zheyang Wu
Researcher at Worcester Polytechnic Institute
Publications - 67
Citations - 976
Zheyang Wu is an academic researcher from Worcester Polytechnic Institute. The author has contributed to research in topics: Statistical power & Genetic association. The author has an hindex of 15, co-authored 63 publications receiving 787 citations. Previous affiliations of Zheyang Wu include University of New Orleans & Yale University.
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Journal ArticleDOI
Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.
Bradley N. Smith,Nicola Ticozzi,Claudia Fallini,Athina Soragia Gkazi,Simon Topp,Kevin P. Kenna,Emma L. Scotter,Jason E. Kost,Pamela Keagle,Jack W. Miller,Daniela Calini,Caroline Vance,Eric Danielson,Claire Troakes,Cinzia Tiloca,Safa Al-Sarraj,Elizabeth A. Lewis,Andrew T. King,Claudia Colombrita,Viviana Pensato,Barbara Castellotti,J. de Belleroche,Frank Baas,A. L. M. A. ten Asbroek,Peter C. Sapp,Diane McKenna-Yasek,Russell L. McLaughlin,Meraida Polak,Seneshaw Asress,Jesús Esteban-Pérez,José Luis Muñoz-Blanco,Michael A. Simpson,W van Rheenen,Frank P. Diekstra,Giuseppe Lauria,Stefano Duga,Stefania Corti,Cristina Cereda,Lucia Corrado,Gianni Sorarù,Karen E. Morrison,Kelly L. Williams,Garth A. Nicholson,Ian P. Blair,Patrick A. Dion,Claire S. Leblond,Guy A. Rouleau,Orla Hardiman,Jan H. Veldink,L. H. van den Berg,Ammar Al-Chalabi,Hardev Pall,Pamela J. Shaw,Martin R Turner,Kevin Talbot,Franco Taroni,Alberto García-Redondo,Zheyang Wu,Jonathan D. Glass,C. Gellera,Antonia Ratti,Robert H. Brown,Vincenzo Silani,Christopher Shaw,John Landers +64 more
TL;DR: In this paper, an exome-wide rare variant burden analysis of 363 index cases with familial ALS (FALS) was performed and the results revealed an excess of patient variants within TUBA4A, the gene encoding the Tubulin, Alpha 4A protein.
Journal ArticleDOI
Interspecific Transfer of Bacterial Endosymbionts between Tsetse Fly Species: Infection Establishment and Effect on Host Fitness
Brian L. Weiss,Rosa Mouchotte,Rita V. M. Rio,Yineng Wu,Zheyang Wu,Abdelaziz Heddi,Serap Aksoy +6 more
TL;DR: The ability to transinfect tsetse flies is indicative of Sodalis ' recent evolutionary history with its t setse fly host and demonstrates that this procedure may be used as a means of streamlining future paratransgenesis experiments.
Journal ArticleDOI
Statistical power of model selection strategies for genome-wide association studies
Zheyang Wu,Hongyu Zhao +1 more
TL;DR: A novel statistical approach for power calculation is developed, accurate formulas for the power of different model selection strategies are derived, and the formulas are utilized to evaluate and compare these strategies in genetic model spaces.
Journal ArticleDOI
Detection boundary and Higher Criticism approach for rare and weak genetic effects
TL;DR: A new theoretical framework in large-scale inference to assess the joint significance of such rare and weak effects for a quantitative trait is developed, and it is shown that the HC-type methods are optimal in that they reliably yield detection once the parameters of the genetic effects fall above the detection boundary.
Journal ArticleDOI
HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer
Marisa Mariani,Mark McHugh,Marco Petrillo,Steven Sieber,Shiquan He,Mirko Andreoli,Mirko Andreoli,Zheyang Wu,Paul Fiedler,Giovanni Scambia,Shohreh Shahabi,Cristiano Ferlini +11 more
TL;DR: Mir-193a-5p, HGF and c-Met expression may help select eligible patients for this modality of treatment, and inhibitors of this pathway may improve the efficacy of NACT.