Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Luca Tamagnone,Stefania Artigiani,Hang Chen,Zhigang He,Guo Li Ming,Hongjun Song,Alain Chédotal,Margaret L. Winberg,Corey S. Goodman,Mu-ming Poo,Marc Tessier-Lavigne,Paolo M. Comoglio +11 more
TLDR
It is concluded that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion.About:
This article is published in Cell.The article was published on 1999-10-01 and is currently open access. It has received 1139 citations till now. The article focuses on the topics: Semaphorin & Plexin.read more
Citations
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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Vascular endothelial growth factor: basic science and clinical progress.
TL;DR: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models and is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration.
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Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
Andrew P. Somlyo,Avril V. Somlyo +1 more
TL;DR: It is suggested that the RhoA/ROK pathway is constitutively active in a number of organs under physiological conditions; its aberrations play major roles in several disease states, particularly impacting on Ca2+ sensitization of smooth muscle in hypertension and possibly asthma and on cancer neoangiogenesis and cancer progression.
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Molecular Mechanisms of Axon Guidance
TL;DR: This work has shown that a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring through signaling pathways still only poorly understood.
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Molecular mechanisms of axon guidance.
TL;DR: It is becoming apparent that molecules previously known for their role in patterning can also direct axonal outgrowth and a sophisticated and dynamic set of cues that enable a growth cone to successfully navigate to its destination, modulating its response to changing environmental cues along its pathway.
References
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Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
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The Molecular Biology of Axon Guidance
TL;DR: Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.
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Oncogenes and signal transduction
Lewis C. Cantley,Kurt R. Auger,Christopher L. Carpenter,Brian C. Duckworth,Andrea Graziani,Rosana Kapeller,Stephen P. Soltoff +6 more
TL;DR: The protein-tyrosine kinase oncogenes will be the primary focus of the review as discussed by the authors, however, biochemical connections between the protein tyrosine Kinases and oncoproteins of the Ras,Raf,Fos,Jun, and Rel families as well as the protein kinase C family are also discussed.
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
TL;DR: It is reported that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue.
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Neuropilin is a semaphorin III receptor.
Alex L. Kolodkin,Dorothy V. Levengood,Erica G. Rowe,Yu Tzu Tai,Roman J. Giger,David D. Ginty +5 more
TL;DR: It is reported that neuropilin, a type I transmembrane protein implicated in aspects of neurodevelopment, is a Sema III receptor and the identification of neuropILin-2, a related neuro pilin family member, is described.
Related Papers (5)
Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
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