Zhihong Tang

TL;DR: Chronic diet intake of anthocyanin-rich extract from black rice may enhance plaque stabilization in old apoE-deficient mice, and the underlying mechanism is related to inhibiting proinflammatory factors and improving the serum lipid profile.

TL;DR: It is demonstrated that anthocyanin induces cholesterol efflux from mouse peritoneal macrophages and macrophage-derived foam cells and that stimulation ofolesterol efflux by anthocianin is mediated, at least in part, by peroxisome proliferator-activated receptor γ-liver X receptor α-ABCA1 signaling pathway activation.

TL;DR: The findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthcyanin.

TL;DR: The results may suggest that BRF could exert cardioprotective effects on patients with CHD by improving plasma antioxidant status and inhibiting inflammatory factors.

TL;DR: In conclusion, leptin promotes inflammation by stimulating TNF-alpha production, which is mediated by cAMP-PKA-ERK1/2 and p38 MAPK pathways.