Z
Zhiyuan Zhang
Researcher at Yale University
Publications - 4
Citations - 521
Zhiyuan Zhang is an academic researcher from Yale University. The author has contributed to research in topics: STAT3 & RANKL. The author has an hindex of 3, co-authored 4 publications receiving 500 citations.
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STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Thomas Welte,Samuel Shao Min Zhang,Tian Wang,Zhiyuan Zhang,David G.T. Hesslein,Zhinan Yin,Arihiro Kano,Yoshiki Iwamoto,Yoshiki Iwamoto,Yoshiki Iwamoto,En Li,Joe Craft,Alfred L. M. Bothwell,Erol Fikrig,Pandelakis A. Koni,Richard A. Flavell,Xin-Yuan Fu +16 more
TL;DR: The results suggest a model in which STAT3 has critical roles in the development and regulation of innate immunity, and deletion of STAT3 during hematopoiesis results in abnormalities in myeloid cells and causes Crohn's disease-like pathogenesis.
Journal ArticleDOI
Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis
TL;DR: SHP-1 plays a role in signals downstream of RANKL by recruitment to the complex containing TRAF6 and these observations may help to understand the mechanism of osteoporosis in Mev/Mev mice.
Journal ArticleDOI
Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice.
TL;DR: It is determined that protein expression and mRNA level of c-fos, a transcription factor which is essential for OC differentiation, were enhanced in OC precursors of mutant mice, which may contribute to the osteopenic phenotype.