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Xin-Yuan Fu
Researcher at National University of Singapore
Publications - 123
Citations - 12613
Xin-Yuan Fu is an academic researcher from National University of Singapore. The author has contributed to research in topics: STAT3 & STAT protein. The author has an hindex of 53, co-authored 122 publications receiving 11810 citations. Previous affiliations of Xin-Yuan Fu include Sichuan University & Southern University of Science and Technology.
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Journal ArticleDOI
Function of Mitochondrial Stat3 in Cellular Respiration
Joanna Wegrzyn,Ramesh Potla,Yong Joon Chwae,Naresh Babu V. Sepuri,Qifang Zhang,Thomas Koeck,Marta Derecka,Marta Derecka,Karol Szczepanek,Karol Szczepanek,Magdalena Szelag,Magdalena Szelag,Agnieszka Gornicka,Agnieszka Gornicka,Akira Moh,Shadi Moghaddas,Qun Chen,Santha Bobbili,Joanna Cichy,Jozef Dulak,Darren P. Baker,Alan Wolfman,Dennis J. Stuehr,Dennis J. Stuehr,Medhat O. Hassan,Xin-Yuan Fu,Narayan G. Avadhani,Jennifer I. Drake,Paul Fawcett,Edward J. Lesnefsky,Edward J. Lesnefsky,Andrew C. Larner +31 more
TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
TL;DR: Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-gamma as mentioned in this paper.
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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
TL;DR: Several antibodies raised against these proteins prove that they indeed do encode protein components of ISGF-3, and provides reagents to explore the modification of this cytoplasmically activated transcription factor.
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Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.
TL;DR: It is shown that activation of the STAT signaling pathway can induce apoptosis through the induction of ICE gene expression, and studies from ICE-deficient cells indicated thatICE gene expression was necessary for IFN-gamma-induced apoptosis.
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The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
TL;DR: It is suggested that proteins encoded by this gene family serve the function of interpreting the fact that a cell surface receptor has bound its ligand so that specific signal transduction to the nucleus can occur.