Z
Zhizeng Gao
Researcher at Sun Yat-sen University
Publications - 31
Citations - 513
Zhizeng Gao is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Neuraminidase & Chemistry. The author has an hindex of 9, co-authored 22 publications receiving 407 citations. Previous affiliations of Zhizeng Gao include University of British Columbia & University of Montana.
Papers
More filters
Journal ArticleDOI
Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs
TL;DR: The complete reconstitution of Rdc5 and Rdc1 activities both in vitro and in Saccharomyces cerevisiae uncovered the earliest resorcylic acid lactone intermediate of the radicicol biosynthetic pathway, (R)-monocillin II.
Journal ArticleDOI
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis.
Hui Zhou,Kangjian Qiao,Zhizeng Gao,Michael J. Meehan,Jesse W.-H. Li,X. Zhao,Pieter C. Dorrestein,John C. Vederas,Yi Tang +8 more
TL;DR: It is shown that the starter-unit:ACP transacylase of Hpm3 is critical for crosstalk between the two enzymes and that the rate of biosynthesis of 1 is determined by the rates of hexaketide formation by Hpm8.
Journal ArticleDOI
A fungal ketoreductase domain that displays substrate-dependent stereospecificity
TL;DR: An unusual level of programming is uncovered by the hypothemycin HR-PKS, in which a single ketoreductase domain displays stereospecificity that is controlled by substrate length.
Journal ArticleDOI
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase.
Ralph A. Cacho,Justin A. J. Thuss,Wei Xu,Randy Sanichar,Zhizeng Gao,Allison Nguyen,John C. Vederas,Yi Tang +7 more
TL;DR: These studies indicate that selective modifications by tailoring domains, such as the MTs, are achieved by higher kinetic efficiency on a particular substrate relative to the rate of transformation by other competing domains.
Journal ArticleDOI
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
Bryan W. Pyle,Hue T. Tran,Benjamin Pickel,Tegan M. Haslam,Zhizeng Gao,Gillian MacNevin,John C. Vederas,Soo-Un Kim,Dae-Kyun Ro +8 more
TL;DR: An integrative approach involving next‐generation sequencing and metabolically engineered microbes to expand the knowledge of terpenoid diversity in medicinal plants is demonstrated.