Zhuo Fu

TL;DR: Evidence that genetic and environmental factors can lead to hyperglycemia, dyslipidemia, inflammation, and autoimmunity, resulting in β-cell dysfunction, thereby triggering the pathogenesis of diabetes is presented.

TL;DR: Dietary intake of genistein significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in streptozotocin-induced diabetic mice, concomitant with improved islet beta-cell proliferation, survival, and mass, demonstrating that geniste in may be a natural antidiabetic agent by directly modulating pancreatic beta- cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway.

TL;DR: The combination of HFD and three 40 mg/kg BW streptozotocin injections induced a model with metabolic characteristics of T2D, including peripheral insulin resistance and reduced β-cell mass.

TL;DR: Two new classes of ncRNAs are identified, stem-bulge RNAs (sbRNAs) and snRNA-likeRNAs (snlRNAs), both featuring distinct internal motifs, secondary structures, upstream elements, and high and developmentally variable expression.

TL;DR: Dietary intake of genistein could prevent T2D via a direct protective action on β-cells without alteration of periphery insulin sensitivity.