Zonghui Yuan

TL;DR: An indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was applied to monitor ivermectin in the milk samples, and the results showed a good correlation with that of HPLC-MS/MS.

TL;DR: A positive correlation (r>0.9249) between the results of the ic-ELISA and the high-performance liquid chromatography were observed, which indicated that the developed ic- ELISA is reliable and can be used to monitor phenothiazines in animal feed.

TL;DR: The metabolism and N-oxide reduction of olaquindox incubated with liver microsomes and liver cytosol of rats, pigs and chicken are presented, suggesting that the N1-reduction and N4-reductions are mediated by multiple mechanisms and significant species differences are involved in both reductions.

TL;DR: The histopathological examinations revealed that 2000mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys.

TL;DR: Long term effects of MEQ on intra- or extra-adrenal renin-angiotensin-aldosterone system (RAAS) in vivo is demonstrated and the complex interactions of drug metabolism, RAAS, NADPH oxidase and oxidative stress in response to MEQ-induced tissue toxicity and aldosterone secretion are highlighted.